Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Rational Design of Network Properties in Guest-Host Assembled and Shear-Thinning Hyaluronic Acid Hydrogels
Biomacromolecules, v 14(11), pp 4125-4134
01 Nov 2013
PMID: 24070551
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Shear-thinning hydrogels afford direct injection or catheter delivery to tissues without potential premature gel formation and delivery failure or the use of triggers such as chemical initiators or heat. However, many shear-thinning hydrogels require long reassembly times or exhibit rapid erosion. We developed a shear-thinning hyaluronic acid (HA) hydrogel based on the guest-host interactions of adamantane modified HA (guest macromer, Ad-HA) and beta-cyclodextrin modified HA (host macromer, CD-HA). The ability of the guest and host molecules to interact with their counterpart following conjugation to HA was confirmed by H-1 NMR spectroscopy and was similar to that of the native complex. Mixing of Ad-HA and CD-HA resulted in rapid formation of a hydrogel composed of guest-host bonds. The hydrogel physical properties, including mechanics and flow characteristics, were dependent on cross-link density and network structure, which were controlled through macromer concentration, the extent of guest macromer modification, and the molar ratio of guest and host functional groups. The guest-host assembly mechanism permitted both shear-thinning behavior for ease of injection and near-instantaneous reassembly for material retention at the target sight. The hydrogel erosion and release of a model biomolecule were also dependent on design parameters and were sustained for over 60 days. These hydrogels show potential as a minimally invasive injectable hydrogel for biomedical applications.
Metrics
Details
- Title
- Rational Design of Network Properties in Guest-Host Assembled and Shear-Thinning Hyaluronic Acid Hydrogels
- Creators
- Christopher B. Rodell - University of PennsylvaniaAdam L. Kaminski - University of PennsylvaniaJason A. Burdick - University of Pennsylvania
- Publication Details
- Biomacromolecules, v 14(11), pp 4125-4134
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 10
- Grant note
- R01 HL107938; R01 HL111090 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Science Foundation MRSEC Award R01HL107938 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000326955900034
- Scopus ID
- 2-s2.0-84887576452
- Other Identifier
- 991019176645104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Organic
- Polymer Science