Journal article
Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project
Journal of the National Cancer Institute. Monographs, v 2014(48), pp 1-14
Aug 2014
PMCID: PMC4155460
PMID: 25174022
Abstract
Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore undertook the NHL Subtypes Project, an international collaborative effort to investigate the etiologies of NHL subtypes. This article describes in detail the project rationale and design.
We pooled individual-level data from 20 case-control studies (17471 NHL cases, 23096 controls) from North America, Europe, and Australia. Centralized data harmonization and analysis ensured standardized definitions and approaches, with rigorous quality control.
The pooled study population included 11 specified NHL subtypes with more than 100 cases: diffuse large B-cell lymphoma (N = 4667), follicular lymphoma (N = 3530), chronic lymphocytic leukemia/small lymphocytic lymphoma (N = 2440), marginal zone lymphoma (N = 1052), peripheral T-cell lymphoma (N = 584), mantle cell lymphoma (N = 557), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (N = 374), mycosis fungoides/Sézary syndrome (N = 324), Burkitt/Burkitt-like lymphoma/leukemia (N = 295), hairy cell leukemia (N = 154), and acute lymphoblastic leukemia/lymphoma (N = 152). Associations with medical history, family history, lifestyle factors, and occupation for each of these 11 subtypes are presented in separate articles in this issue, with a final article quantitatively comparing risk factor patterns among subtypes.
The International Lymphoma Epidemiology Consortium NHL Subtypes Project provides the largest and most comprehensive investigation of potential risk factors for a broad range of common and rare NHL subtypes to date. The analyses contribute to our understanding of the multifactorial nature of NHL subtype etiologies, motivate hypothesis-driven prospective investigations, provide clues for prevention, and exemplify the benefits of international consortial collaboration in cancer epidemiology.
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Details
- Title
- Rationale and Design of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma Subtypes Project
- Creators
- Lindsay M Morton - National Institutes of HealthJoshua N Sampson - National Institutes of HealthJames R Cerhan - Mayo Clinic Rochester, MNJennifer J Turner - Macquarie UniversityClaire M Vajdic - UNSW SydneySophia S Wang - City Of Hope National Medical CenterKarin E Smedby - Karolinska InstituteSilvia de Sanjosé - Centro de Investigación Biomédica en Red de CáncerAlain Monnereau - University of BordeauxYolanda Benavente - Centro de Investigación Biomédica en Red de CáncerPaige M Bracci - University of California, San FranciscoBrian C H Chiu - University of ChicagoChristine F Skibola - University of AlabamaYawei Zhang - Yale UniversitySam M Mbulaiteye - National Institutes of HealthMichael Spriggs - Information Management SystemsDennis Robinson - Mayo Clinic Rochester, MNAaron D Norman - Mayo Clinic Rochester, MNEleanor V Kane - University of YorkJohn J Spinelli - University of British ColumbiaJennifer L Kelly - University of RochesterCarlo La Vecchia - University of MilanLuigino Dal MasoMarc Maynadié - University of BurgundyMarshall E Kadin - Roger Williams Medical CenterPierluigi Cocco - University of CagliariAdele Seniori Costantini - Cancer Prevention and Research Institute ISPOChristina A Clarke - Cancer Prevention Institute of CaliforniaEve Roman - University of YorkLucia Miligi - Cancer Prevention and Research Institute ISPOJoanne S Colt - National Institutes of HealthSonja I Berndt - National Institutes of HealthAndrea MannetjeAnneclaire J de Roos - Drexel UniversityAnne Kricker - University of SydneyAlexandra Nieters - University of FreiburgSilvia Franceschi - International Agency For Research On CancerMads Melbye - Statens Serum InstitutPaolo Boffetta - Icahn School of Medicine at Mount SinaiJacqueline Clavel - University of Paris-SudMartha S Linet - National Institutes of HealthDennis D Weisenburger - City Of Hope National Medical CenterSusan L Slager - Mayo Clinic Rochester, MN
- Publication Details
- Journal of the National Cancer Institute. Monographs, v 2014(48), pp 1-14
- Publisher
- Oxford University Press
- Grant note
- K23 CA102216 / NCI NIH HHS N01-PC-67008 / NCI NIH HHS CA150037 / NCI NIH HHS P30 CA033572 / NCI NIH HHS CA165923 / NCI NIH HHS N01-CP-ES-11027 / NCI NIH HHS R01 CA92153 / NCI NIH HHS CA143947 / NCI NIH HHS P50 CA097274 / NCI NIH HHS Canadian Institutes of Health Research Intramural NIH HHS R01 CA92153-S1 / NCI NIH HHS P50 CA130805 / NCI NIH HHS UL 1 RR024160 / NCRR NIH HHS N01-PC-67009 / NCI NIH HHS N01-PC-65064 / NCI NIH HHS R01 CA14690 / NCI NIH HHS R01CA154643-01A1 / NCI NIH HHS T32 HL007152 / NHLBI NIH HHS R01CA122663 / NCI NIH HHS R01 CA50850 / NCI NIH HHS P50 CA97274 / NCI NIH HHS R01CA087014 / NCI NIH HHS CA51086 / NCI NIH HHS CA62006 / NCI NIH HHS N02-PC-71105 / NCI NIH HHS R01CA104682 / NCI NIH HHS R03CA132153 / NCI NIH HHS UL1 TR000430 / NCATS NIH HHS R03CA125831 / NCI NIH HHS N01-CP-95618 / NCI NIH HHS N01-PC-67010 / NCI NIH HHS R01CA45614 / NCI NIH HHS U01 CA118444 / NCI NIH HHS R13 CA159842 01 / NCI NIH HHS 5R01 CA69669-02 / NCI NIH HHS R01CA100555 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Scopus ID
- 2-s2.0-84906823421
- Other Identifier
- 991019173675104721