Journal article
Reactogenicity and immunogenicity of a three-component acellular pertussis vaccine administered as the primary series to 2, 4 and 6 month old infants in the United States
Vaccine, v 13(17), pp 1631-1635
1995
PMID: 8719512
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Five hundred and fifty-seven infants received either an acellular pertussis (DTaP) vaccine containing pertussis toxoid (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) or one of two commercially available whole-cell pertussis (DTP) vaccines at 2, 4 and 6 months. One month after the third immunization, IgG antibody values to pertussis toxoid, filamentous hemagglutinin and PRN were significantly greater following DTaP than either DTP (
P<0.05). When reactions within 48 h after all three doses of vaccine were combined, fever 101°, ≥moderate fussiness, ≥moderate pain, swelling 10 mm, and erythema 10 mm occurred less often after DTaP compared with DTP-Connaught (
P<0.001). The same adverse events were also less after DTaP compared with DTP-Lederle (
P<0.05), except for erythema 10 mm. This three-component DTaP vaccine produced fewer adverse events and greater antibody values to PT, FHA and PRN in comparison with either licensed DTP vaccine when given as the primary series.; Acellular pertussis vaccine; whole-cell pertussis vaccine; immunization
Metrics
Details
- Title
- Reactogenicity and immunogenicity of a three-component acellular pertussis vaccine administered as the primary series to 2, 4 and 6 month old infants in the United States
- Creators
- Henry H. Bernstein - St. Christopher's Hospital for ChildrenEdward P. Rothstein - St. Christopher's Hospital for ChildrenPennridge Pediatric Associates - Temple UniversityMichael E. Pichichero - University of RochesterJohn L. Green - University of RochesterElmwood Pediatrics - University of RochesterKeith S. Reisinger - University of RochesterMark M. Blatter - Pittsburgh Pediatric Research Inc., Pittsburgh, PA, USAJudith Halpern - Einstein Medical Center PhiladelphiaAllan M. Arbeter - Einstein Medical Center PhiladelphiaDavid I. Bernstein - J.N. Gamble Institute of Medical Research, Cincinnati, OH, USAVicki Smith - J.N. Gamble Institute of Medical Research, Cincinnati, OH, USASarah S. Long - St. Christopher's Hospital for ChildrenHal Rathfon - SmithKline BeechamDavid S. Krause - SmithKline Beecham
- Publication Details
- Vaccine, v 13(17), pp 1631-1635
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:A1995TL90000001
- Scopus ID
- 2-s2.0-9044253706
- Other Identifier
- 991019335481804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental