Journal article
Readmission rate after ultrafiltration in acute decompensated heart failure: a systematic review and meta-analysis
Heart failure reviews, v 22(6), pp 685-698
01 Nov 2017
PMID: 28900774
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Significance of ultrafiltration in acute decompensated heart failure remains unclear. We performed meta-analysis to determine its role in reducing readmissions after acute decompensated heart failure. MEDLINE was searched using PUBMED from inception to March 22, 2017 for prospective randomized control trials comparing ultrafiltration to diuretics in acute decompensated heart failure. Five hundred ninety studies were found; nine studies with 820 patients were included. Studies with renal replacement therapy bar ultrafiltration, chronic decompensated heart failure, and non-English language were excluded. RevMan Version 5.3 was used for analysis. The primary outcomes analyzed were cumulative and 90 days readmissions secondary to heart failure and all-cause readmissions. Baseline characteristics were similar. One hundred eighty-eight patients were readmitted with heart failure, 77 vs 111 favoring ultrafiltration; risk ratio (RR) = 0.71 (95% confidence interval (CI), 0.49-1.02, p = 0.07, I (2) = 47%). Ninety days readmissions were 43 vs 67 favoring ultrafiltration; RR = 0.65 (95%CI, 0.47-0.90, p = 0.01, I-2 = 0%). Ultrafiltration showed significantly higher fluid removal and weight loss. Hypotension was common in ultrafiltration (24 vs 13, OR = 2.06, 95%CI = 0.98-4.32, p = 0.06, I-2 = 0%). Ultrafiltration showed reduced 90 days heart failure readmissions and trend towards reduced cumulative hospital readmissions. Renal and cardiovascular outcomes and hospital stay were similar.
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Details
- Title
- Readmission rate after ultrafiltration in acute decompensated heart failure: a systematic review and meta-analysis
- Creators
- Waqas Javed Siddiqui - Drexel UniversityAndrew R. Kohut - Drexel UniversitySyed F. Hasni - Drexel UniversityJesse M. Goldman - Drexel UniversityBenjamin Silverman - Drexel UniversityEllie Kelepouris - Drexel UniversityHoward J. Eisen - Drexel UniversitySandeep Aggarwal - Drexel University
- Publication Details
- Heart failure reviews, v 22(6), pp 685-698
- Publisher
- Springer Nature
- Number of pages
- 14
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Nephrology (and Hypertension)
- Web of Science ID
- WOS:000412841100005
- Scopus ID
- 2-s2.0-85029183726
- Other Identifier
- 991019318943904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems