Journal article
Real-time Feedback to Improve HIV Treatment Adherence in Pregnant and Postpartum Women in Uganda: A Randomized Controlled Trial
AIDS and behavior, v 26(12), pp 3834-3847
01 Dec 2022
PMID: 35704124
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We assessed an intervention aimed at improving adherence to antiretroviral therapy (ART) among pregnant and postpartum women living with HIV (PPWLH). We randomized 133 pregnant women initiating ART in Uganda to receive text reminders generated by real time-enabled electronic monitors and data-informed counseling through 3 months postpartum (PPM3) or standard care. Intention-to-treat analyses found low adherence levels and no intervention impact. Proportions achieving >= 95% adherence in PPM3 were 16.4% vs. 9.1% (t = -1.14, p = 0.26) in intervention vs. comparison groups, respectively; 30.9% vs. 29.1% achieved >= 80% adherence. Additional analyses found significant adherence declines after delivery, and no effect on disease progression (CD4-cell count, viral load), though treatment interruptions were significantly fewer in intervention participants. Per-protocol analyses encompassing participants who used adherence monitors as designed experienced better outcomes, suggesting potential benefit for some PPWLH. The study was registered on ClinicalTrials.Gov (NCT02396394).
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Details
- Title
- Real-time Feedback to Improve HIV Treatment Adherence in Pregnant and Postpartum Women in Uganda: A Randomized Controlled Trial
- Creators
- Lora L. Sabin - Boston UniversityElizabeth Simmons - Boston UniversityNafisa Halim - Boston UniversityDavidson H. Hamer - Boston UniversityAllen L. Gifford - Boston UniversityRebecca L. West - Boston UniversityAnna Larson - Boston UniversityRachael Bonawitz - Boston UniversityPhilip Aroda - Mildmay UgandaBolanle Banigbe - Boston UniversityAlayna J. Holderman - University of PittsburghLisa Murray - Boston UniversityMary B. DeSilva - University of New EnglandJulia Gasuza - Mildmay UgandaBarbara Mukasa - Mildmay UgandaLisa J. Messersmith - Boston University
- Publication Details
- AIDS and behavior, v 26(12), pp 3834-3847
- Publisher
- Springer Nature
- Number of pages
- 14
- Grant note
- NIH/NIMH 1R34MN103075 / United States National Institutes of Health, Institute for Mental Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000811443900002
- Scopus ID
- 2-s2.0-85132122735
- Other Identifier
- 991021448041804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health
- Social Sciences, Biomedical