Journal article
Real-time, label-free, all-electrical detection of Salmonella typhimurium using lead titanate zirconate/gold-coated glass cantilevers at any relative humidity
Sensors and actuators. B, Chemical, v 125(2), pp 379-388
08 Aug 2007
PMID: 22872784
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have examined non-insulated PZT/gold-coated glass cantilevers for real-time, label-free detection of Salmonella typhimurium by partial dipping at any relative humidity. The PZT/gold-coated glass cantilevers consisted of a 0.127mm-thick PZT layer about 0.8mm long, 2mm wide bonded to a 0.15mm-thick gold-coated glass layer with a 3.0mm-long gold-coated glass tip for detection. We showed that by placing the water level at the nodal point, about 0.8mm from the free end of the gold-glass tip, there was a 1/2-h window in which the resonance frequency was stable despite the water level change due to evaporation at 20% relative humidity or higher. By dipping the cantilevers to their nodal point, we were able to do real-time, label-free detection without background resonance frequency corrections at any relative humidity. The partially dipped PZT/gold-coated glass cantilever exhibited mass detection sensitivity, Δm/Δf=−5×10−11g/Hz, and a detection concentration sensitivity, 5×103cells/ml in 2ml of liquid, which was about two orders of magnitude lower than that of a 5MHz QCM. It was also about two orders of magnitude lower than the infectious dose and one order of magnitude lower that the detection limit of a commercial Raptor sensor.
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Details
- Title
- Real-time, label-free, all-electrical detection of Salmonella typhimurium using lead titanate zirconate/gold-coated glass cantilevers at any relative humidity
- Creators
- Qing Zhu - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, United StatesWan Y Shih - School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104, United StatesWei-Heng Shih - Department of Materials Science and Engineering, Drexel University, Philadelphia, PA 19104, United States
- Publication Details
- Sensors and actuators. B, Chemical, v 125(2), pp 379-388
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Materials Science and Engineering
- Web of Science ID
- WOS:000248956900005
- Scopus ID
- 2-s2.0-34447646890
- Other Identifier
- 991014877941004721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Analytical
- Electrochemistry
- Instruments & Instrumentation