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Journal article
Reappearance from Obscurity: Mammalian Rad52 in Homologous Recombination
Genes, v 7(9)
01 Sep 2016
PMID: 27649245
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Homologous recombination (HR) plays an important role in maintaining genomic integrity. It is responsible for repair of the most harmful DNA lesions, DNA double-strand breaks and inter-strand DNA cross-links. HR function is also essential for proper segregation of homologous chromosomes in meiosis, maintenance of telomeres, and resolving stalled replication forks. Defects in HR often lead to genetic diseases and cancer. Rad52 is one of the key HR proteins, which is evolutionarily conserved from yeast to humans. In yeast, Rad52 is important for most HR events; Rad52 mutations disrupt repair of DNA double-strand breaks and targeted DNA integration. Surprisingly, in mammals, Rad52 knockouts showed no significant DNA repair or recombination phenotype. However, recent work demonstrated that mutations in human RAD52 are synthetically lethal with mutations in several other HR proteins including BRCA1 and BRCA2. These new findings indicate an important backup role for Rad52, which complements the main HR mechanism in mammals. In this review, we focus on the Rad52 activities and functions in HR and the possibility of using human RAD52 as therapeutic target in BRCA1 and BRCA2-deficient familial breast cancer and ovarian cancer.
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Details
- Title
- Reappearance from Obscurity: Mammalian Rad52 in Homologous Recombination
- Creators
- Kritika Hanamshet - Drexel UniversityOlga M. Mazina - Drexel UniversityAlexander V. Mazin - Drexel University
- Publication Details
- Genes, v 7(9)
- Publisher
- Mdpi
- Number of pages
- 18
- Grant note
- J.N.Tata Trust Endowment scholarship (India) Basser Innovation Award R01GM115927 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) CA188347; GM115927-01 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01CA188347 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Drexel Clinical Translational Research Institute (CTRI) award
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000385535300009
- Scopus ID
- 2-s2.0-84989326340
- Other Identifier
- 991019168016604721
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- Web of Science research areas
- Genetics & Heredity