Journal article
Recent exposure to particulate matter and C-reactive protein concentration in the multi-ethnic study of atherosclerosis
American journal of epidemiology, v 164(5), pp 437-448
01 Sep 2006
PMID: 16751260
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ambient levels of particulate matter have been linked to cardiovascular disease. The mechanisms mediating these associations are poorly understood. One candidate mechanism is inflammation. Using data from the Multi-Ethnic Study of Atherosclerosis (2000–2002), the authors investigated the relation between exposure to particulate matter of less than or equal to 2.5 μm in diameter (PM2.5) and C-reactive protein concentration in 5,634 persons aged 45–84 years who were free of cardiovascular disease. Data from US Environmental Protection Agency monitors were used to estimate PM2.5 exposures for the prior day, prior 2 days, prior week, prior 30 days, and prior 60 days. Only the 30-day and 60-day mean exposures showed a weak positive association with C-reactive protein, and confidence intervals were wide: relative increases in C-reactive protein per 10 μg/m3 of PM2.5 adjusted for person-level covariates were 3% (95% confidence interval (CI): –2, 10) for a 30-day mean and 4% (95% CI: –3, 11.0) for a 60-day mean. The means of 7-day, 30-day, and 60-day exposures were weakly, positively, and nonsignificantly associated with the odds of C-reactive protein of greater than or equal to 3 mg/liter: adjusted odds ratios were 1.05 (95% CI: 0.96, 1.15), 1.12 (95% CI: 0.98, 1.29), and 1.12 (95% CI: 0.96, 1.32), respectively. Slightly stronger associations were observed in persons without other risk factors for elevated C-reactive protein, but this heterogeneity was not statistically significant. The authors' results are not compatible with strong effects of particulate matter exposures on population levels of C-reactive protein.
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Details
- Title
- Recent exposure to particulate matter and C-reactive protein concentration in the multi-ethnic study of atherosclerosis
- Creators
- Ana V.Diez Roux (Corresponding Author) - University of MichiganA. H. Auchincloss - University of MichiganB. Astor - University of WashingtonR. G. Barr - Columbia University Irving Medical CenterM. Cushman - Department of Pathology, University of Vermont, United StatesT. Dvonch - Department of Environmental Health Sciences, School of Public Health, University of Michigan, United StatesD. R. Jacobs - University of MinnesotaJ. Kaufman - University of WashingtonX. Lin - University of MichiganP. Samson - Department of Atmospheric Sciences, School of Engineering, University of Michigan, United States
- Publication Details
- American journal of epidemiology, v 164(5), pp 437-448
- Publisher
- Oxford University Press
- Number of pages
- 12
- Grant note
- National Institute of Environmental Health Sciences (http://data.elsevier.com/vocabulary/SciValFunders/100000066) U.S. Environmental Protection Agency (http://data.elsevier.com/vocabulary/SciValFunders/100000139) K24ES013195 / National Institute of Environmental Health Sciences (http://data.elsevier.com/vocabulary/SciValFunders/100000066) R830543 / National Heart, Lung, and Blood Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000050) National Heart, Lung, and Blood Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000050)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000240286600004
- Scopus ID
- 2-s2.0-33749077747
- Other Identifier
- 991014878398504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health