Journal article
Receptor for advanced glycation end products and neuronal deficit in the fatal brain edema of diabetic ketoacidosis
Brain research, v 1238
2008
PMID: 18775683
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Radiologic and neuropsychologic studies suggest that diabetes mellitus causes structural changes in the brain and adversely effects cognitive development. Experimental animal models of type 1 diabetes mellitus (T1DM) have advanced these findings by demonstrating duration-related neuronal and cognitive deficits in T1DM BB/Wor rats. We studied the expression of receptor for advanced glycation end products (RAGE) and neuronal densities in the brains of two patients who died as the result of clinical brain edema(BE)that developed during the treatment of severe diabetic ketoacidosis (DKA). RAGE was markedly and diffusely expressed in blood vessels, neurons, and the choroid plexus and co-localized with glial fibrillary acidic protein (GFAP) in astrocytes. Significant neuronal loss was seen in the hippocampus and frontal cortex. Astrocytosis was present and white matter was atrophied in both cases when compared to age-matched controls. Our data supports that a neuroinflammatory response occurs in the BE associated with DKA, and that even after a relatively short duration of poorly controlled T1DM, the pathogenesis of primary diabetic encephalopathy can be initiated.
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Details
- Title
- Receptor for advanced glycation end products and neuronal deficit in the fatal brain edema of diabetic ketoacidosis
- Creators
- William H Hoffman - Section of Pediatric Endocrinology, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USACarol M Artlett - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USAWeixian Zhang - Department of Pathology, Neurology, and Morris J. Hood Jr. Comprehensive Diabetes Center, Wayne State University School of Medicine, Detroit, MI 48201, USAChristian W Kreipke - Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USAGregory G Passmore - Department of Radiologic Sciences, Medical College of Georgia, Augusta, GA 30912, USAJose A Rafols - Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USAAnders A.F Sima - Department of Pathology, Neurology, and Morris J. Hood Jr. Comprehensive Diabetes Center, Wayne State University School of Medicine, Detroit, MI 48201, USA
- Publication Details
- Brain research, v 1238
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000260858100016
- Scopus ID
- 2-s2.0-55349091659
- Other Identifier
- 991014878025604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences