Journal article
Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients
Neuroscience letters, v 173(1)
1994
PMID: 7936419
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effects of Alzheimer's disease (AD) on [
35S]GTPγS binding to G proteins was examined in postmortem cerebrocortex. Stimulation of the β-adrenergic or muscarinic cholinergic receptors in control tissue with selective agonists resulted in increases in [
35S]GTPγS binding to Gα proteins in a receptor-specific fashion. The responses were markedly reduced in brain tissues from AD patients. In contrast, basal [
35S]GTPγS binding to the Gα proteins was relatively intact in AD brains. Immunoblot analyses reveal that levels of cerebrocortical Gα proteins in AD are not altered. The results suggest that in AD the decrease in agonist-stimulated [
35S]GTPγS binding to G proteins may be a result of decoupling between receptors and their associated G proteins.
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Details
- Title
- Receptor-mediated activation of G proteins is reduced in postmortem brains from Alzheimer's disease patients
- Creators
- Hoau-Yan Wang - Drexel UniversityEitan Friedman - Drexel University
- Publication Details
- Neuroscience letters, v 173(1)
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1994PF44800009
- Scopus ID
- 2-s2.0-0028304198
- Other Identifier
- 991019183990004721
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- Web of Science research areas
- Neurosciences