Journal article
Reciprocal functional pseudotyping of HIV-1 and HTLV-1 viral genomes by the heterologous counterpart envelope proteins
Virology (New York, N.Y.), v 443(1), pp 106-112
15 Aug 2013
PMID: 23747197
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV-1 and HTLV-1 can infect CD4+ T cells and can co-infect the same individual. In principle, it is possible that both viruses can infect the same CD4+ T cells in dually infected persons. Currently, how efficiently HTLV-1 and HIV-1 co-infects the same cell and the full extent of their biological interactions are not well-understood. Here, we report evidence confirming that both viruses can infect the same cells and that HTLV-1 envelope (Env) can pseudotype HIV-1 viral particles and HIV-1 envelope (Env) can pseudotype HTLV-1 virions to mediate subsequent infections of substrate cells. We also show that the construction of a chimeric HTLV-1 molecular clone carrying the HIV-1 Env in place of its HTLV-1 counterpart results in a replication competent moiety. These findings raise new implications of viral complementation and assortment between HIV-1 and HTLV-1 in dually infected persons.
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Details
- Title
- Reciprocal functional pseudotyping of HIV-1 and HTLV-1 viral genomes by the heterologous counterpart envelope proteins
- Creators
- Zachary Klase - National Institute of Allergy and Infectious DiseasesKuan-Teh Jeang
- Publication Details
- Virology (New York, N.Y.), v 443(1), pp 106-112
- Publisher
- Elsevier
- Grant note
- Z99 AI999999 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000322289900012
- Scopus ID
- 2-s2.0-84879786177
- Other Identifier
- 991021902597504721
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- Web of Science research areas
- Virology