Journal article
Recombinant human granulocyte colony-stimulating factor reduces hepatitis c virus replication in mononuclear cells from chronic hepatitis c patients
Cytokine (Philadelphia, Pa.), v 8(4), pp 313-317
01 Apr 1996
PMID: 9162221
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hepatitis C virus infects mononuclear leukocytes of patients with chronic hepatitis C. Treatment with rhG-CSF led to a dose-related reduction in the genomic and antigenomic hepatitis C viral strands in cultures of mitogen-stimulated, naturally-infected peripheral blood mononuclear cells from patients with chronic hepatitis C. Hepatitis C virus genomic strand of subtype 1b was suppressed in 5 of 11 cases, and concurrently with suppression of the viral antigenomic strand in two of them. The treatment also resulted in a significantly increased release of interleukin 6, but not of other cytokines. However, the biological response of hepatitis C virus-infected mononuclear cells to treatment with recombinant human granulocyte colony-stimulating factor was unrelated to any particular pattern of cytokine production.
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Details
- Title
- Recombinant human granulocyte colony-stimulating factor reduces hepatitis c virus replication in mononuclear cells from chronic hepatitis c patients
- Creators
- Sonia Navas - Drexel University, Microbiology and ImmunologyJuan Antonio Quiroga - Hospital Universitario Fundación Jiménez DíazVicente Carreño - Fundación para el Estudio de las Hepatitis Virales
- Publication Details
- Cytokine (Philadelphia, Pa.), v 8(4), pp 313-317
- Publisher
- Elsevier
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1996UF85000007
- Scopus ID
- 2-s2.0-0029878624
- Other Identifier
- 991022047819004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology