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Recommendations of the National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group
Journal article   Open access   Peer reviewed

Recommendations of the National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group

Jeffrey Platt, Verdi DiSesa, Dorothy Gail, Judith Massicot-Fisher and National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group
Circulation (New York, N.Y.), v 106(9), pp 1043-1047
27 Aug 2002
PMID: 12196325
url
https://doi.org/10.1161/01.CIR.0000031064.67525.28View
Published, Version of Record (VoR) Open

Abstract

The National Heart, Lung, and Blood Institute (NHLBI) recently convened the Heart and Lung Xenotransplantation Working Group to identify hurdles to the clinical application of xenotransplantation, defined as the use of animal organs or tissue for transplantation, and to recommend possible solutions to these problems. The group consisted of experts in xenotransplantation from academia, industry, and federal agencies, and the discussions focused on those areas within the mission of the NHLBI. The areas covered included immunologic and physiological barriers to xenotransplantation, the limitations of the current animal models, the need for collaboration among groups, the high costs of studies using nonhuman primates and genetic engineering of pigs, and the unique problems of lung xenotransplantation. This report is a summary of those discussions.

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Collaboration types
Domestic collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
Peripheral Vascular Disease
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