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Reconstitution of cell membrane structure in vitro and its transformation into an excitable system
Journal article   Peer reviewed

Reconstitution of cell membrane structure in vitro and its transformation into an excitable system

Paul Mueller, Donald O. Rudin, H. Ti Tien and William C. Wescott
Nature (London), v 194(4832), pp 979-980
09 Jun 1962
PMID: 14476933

Abstract

THE formation of single, stable bimolecular lipid and proteolipid1 membranes up to 10 mm.2 in area has been accomplished routinely in 0.1 M saline solution by methods analogous to the formation of Hooke-Newton ‘secondary black’ in air soap films2–4. By forming such a membrane between two compartments filled with saline its transverse electrical properties can be measured, and controlled chemical investigations can be undertaken.

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