Journal article
Reconstruction of tumor microenvironment via in vitro three-dimensional models
Biofabrication, v 15(3), 032002
01 Jul 2023
PMID: 37130516
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent advances in tumor microenvironment (TME) modeling as well as its applications to cancer therapy has brought various dramatical changes in multiple malignancies management. Understanding the mechanisms of response and resistance to cancer therapy requires a clear elucidation of the intricate interactions between TME cells, the surrounding stroma, and distant affected tissues or organs. To address this demand, various three-dimensional (3D) cell culture techniques have been developed in order to recapitulate and understand cancer biology over the past decade. This review summarizes some saliant progresses in in vitro 3D TME modeling, including the cell-based, matrix-based, and vessel-based dynamic 3D modeling techniques and their applications in investigating tumor-stroma interactions and responses to cancer therapies. The review also discusses the limitations of current TME modeling approaches and proposes some new thoughts on the construction of more clinically relevant models.
Metrics
1 Record Views
Details
- Title
- Reconstruction of tumor microenvironment via in vitro three-dimensional models
- Creators
- Zhenzhen Zhou - Key Laboratory for Advanced Materials Processing Technology, Ministry of Education , Beijing 100084, People’s Republic of ChinaJianyu He - Key Laboratory for Advanced Materials Processing Technology, Ministry of Education , Beijing 100084, People’s Republic of ChinaYuan Pang - Key Laboratory for Advanced Materials Processing Technology, Ministry of Education , Beijing 100084, People’s Republic of ChinaWei Sun - Drexel University
- Publication Details
- Biofabrication, v 15(3), 032002
- Publisher
- IOP Publishing
- Number of pages
- 16
- Grant note
- 3212007 / Beijing Natural Science Foundation 20223930093 / Tsinghua-Toyota Joint Research Fund B17026 / 111 Project 2018YFA0703004 / Research and Development Program of China 52175273; 52211540006; 82072837 / National Natural Science Foundation of China (http://dx.doi.org/10.13039/501100001809) 20213080030; 2022ZLB004 / Initiative Scientific Research Program 20220484075 / Beijing Nova Program (http://dx.doi.org/10.13039/501100005090) 2022NSCQ-LZX0326 / Natural Science Foundation of Chongqing (http://dx.doi.org/10.13039/501100005230)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000992552800001
- Scopus ID
- 2-s2.0-85160003894
- Other Identifier
- 991022207176904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials