Journal article
Rectal administration of N-acetylcysteine in swine: a pilot study
Veterinary and human toxicology, v 39(6), pp 329-331
Dec 1997
PMID: 9397498
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this pilot study was to determine if N-acetylcysteine (NAC) administered via the rectal route in swine is absorbed into the systemic circulation. Fasting swine were anesthetized, intubated, monitored and i.v. access was obtained by femoral cutdown. NAC was administered into the rectal vault (2.0 g/kg) via a balloon-tipped Foley catheter inserted into the animals' rectum. NAC administered via the rectal route resulted in systemic absorption as determined by spectrophotometric methods in 5 of the 7 study animals. This study provides important information regarding the development of a potential alternative route for the administration of NAC.
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Details
- Title
- Rectal administration of N-acetylcysteine in swine: a pilot study
- Creators
- M I Greenberg - Department of Emergency Medicine, Allegheny University of the Health Sciences, Philadelphia, PA 19129, USAH GraziosoD DiSandroS StillerA P Ferko
- Publication Details
- Veterinary and human toxicology, v 39(6), pp 329-331
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:A1997YG59400001
- Scopus ID
- 2-s2.0-0030686522
- Other Identifier
- 991019168317004721
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- Web of Science research areas
- Toxicology
- Veterinary Sciences