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Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study
Journal article   Open access   Peer reviewed

Recurrence Risk of Autism in Siblings and Cousins: A Multinational, Population-Based Study

Stefan N. Hansen, Diana E. Schendel, Richard W. Francis, Gayle C. Windham, Michaeline Bresnahan, Stephen Z. Levine, Abraham Reichenberg, Mika Gissler, Arad Kodesh, Dan Bai, …
Journal of the American Academy of Child and Adolescent Psychiatry, v 58(9), pp 866-875
01 Sep 2019
DOI: https://doi.org/10.1016/j.jaac.2018.11.017
PMID: 30851399
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc6708733View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

autism familial risk longitudinal multinational recurrence
Familial recurrence risk is an important population-level measure of the combined genetic and shared familial liability of autism spectrum disorder (ASD). Objectives were to estimate ASD recurrence risk among siblings and cousins by varying degree of relatedness and by sex. This is a population-based cohort study of livebirths from 1998 to 2007 in California, Denmark, Finland, Israel, Sweden and Western Australia followed through 2011 to 2015. Subjects were monitored for an ASD diagnosis in their older siblings or cousins (exposure) and for their ASD diagnosis (outcome). The relative recurrence risk was estimated for different sibling and cousin pairs, for each site separately and combined, and by sex. During follow-up, 29,998 cases of ASD were observed among the 2,551,918 births used to estimate recurrence in ASD and 33,769 cases of childhood autism (CA) were observed among the 6,110,942 births used to estimate CA recurrence. Compared with the risk in unaffected families, there was an 8.4-fold increase in the risk of ASD following an older sibling with ASD and a 17.4-fold increase in the risk of CA following an older sibling with CA. A 2-fold increase in the risk for cousin recurrence was observed for the 2 disorders. There also was a significant difference in sibling ASD recurrence risk by sex. The present estimates of relative recurrence risks for ASD and CA will assist clinicians and families in understanding autism risk in the context of other families in their population. The observed variation by sex underlines the need to deepen the understanding of factors influencing ASD familial risk.

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Pediatrics
Psychiatry
Psychology, Developmental
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