Journal article
Recurrent HBV Integration Targets as Potential Drivers in Hepatocellular Carcinoma
Cells (Basel, Switzerland), v 10(6), p1294
23 May 2021
PMID: 34071075
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic hepatitis B virus (HBV) infection is the major etiology of hepatocellular carcinoma (HCC), frequently with HBV integrating into the host genome. HBV integration, found in 85% of HBV-associated HCC (HBV-HCC) tissue samples, has been suggested to be oncogenic. Here, we investigated the potential of HBV-HCC driver identification via the characterization of recurrently targeted genes (RTGs). A total of 18,596 HBV integration sites from our in-house study and others were analyzed. RTGs were identified by applying three criteria: at least two HCC subjects, reported by at least two studies, and the number of reporting studies. A total of 396 RTGs were identified. Among the 28 most frequent RTGs, defined as affected in at least 10 HCC patients, 23 (82%) were associated with carcinogenesis and 5 (18%) had no known function. Available breakpoint positions from the three most frequent RTGs, TERT, MLL4/KMT2B, and PLEKHG4B, were analyzed. Mutual exclusivity of TERT promoter mutation and HBV integration into TERT was observed. We present an RTG consensus through comprehensive analysis to enable the potential identification and discovery of HCC drivers for drug development and disease management.
Metrics
Details
- Title
- Recurrent HBV Integration Targets as Potential Drivers in Hepatocellular Carcinoma
- Creators
- Selena Y. Lin - JBS Science (United States)Adam Zhang - Baruch S. Blumberg InstituteJessica Lian - Baruch S Blumberg Res Inst, Doylestown, PA 18902 USAJeremy Wang - JBS Science (United States)Ting-Tsung Chang - National Cheng Kung UniversityYih-Jyh Lin - National Cheng Kung UniversityWei Song - JBS Science (United States)Ying-Hsiu Su - Baruch S. Blumberg Institute
- Publication Details
- Cells (Basel, Switzerland), v 10(6), p1294
- Publisher
- Mdpi
- Number of pages
- 16
- Grant note
- R43 CA165312; R44 CA165312; R43 CA192507 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000667838000001
- Scopus ID
- 2-s2.0-85107400392
- Other Identifier
- 991021463429004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- International collaboration
- Web of Science research areas
- Cell Biology