Journal article
Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With RRP
The Laryngoscope, Forthcoming
16 Jan 2026
PMID: 41543033
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
With regulatory approval of HPV-specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted.
RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm for adults with RRP considering published literature and commercial drug availability.
Preventative HPV vaccination should be considered for all patients. Determination of HPV type and pulmonary imaging are important for contemporary RRP patient care and assist in decision making. Risks and benefits of papilloma debulking as needed versus medical management of RRP must be deliberated on a patient case-by-case basis. HPV-specific immunotherapy that induces an HPV-specific T cell response to target the underlying HPV infection that is the cause of RRP is safe, offers the possibility of durable disease control following a short treatment course and is the recommended first-line medical treatment for patients who wish to avoid the risks of repeat procedural management. Papilloma disease control with systemic bevacizumab, which carries defined risks and must be continued for clinical benefit is the recommended second-line medical treatment for patients who do not achieve a complete response with immunotherapy and wish to continue medical management. For patients who elect to be treated with debulking procedures as needed, use of locally-administered adjuvant should be considered.
This proposed management algorithm from the RRPF serves as a contemporary resource and information guide for adult patients with RRP and their physicians considering treatment options.
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Details
- Title
- Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With RRP
- Creators
- Simon R Best (Corresponding Author) - Johns Hopkins UniversityAaron D Friedman - University of CincinnatiClark A Rosen - University of California, San FranciscoRobert T Sataloff - Drexel UniversityLaura A Matrka - The Ohio State UniversityH Steven Sims - Rush UniversityDavid E Rosow - University of MiamiNabil F Saba - Emory UniversityDavid G Lott - Mayo Clinic in ArizonaAdam M Klein - Emory UniversityTed Mau - Palo Alto UniversityMilan R Amin - New York UniversityKathryn A Wikenheiser-Brokamp - Perinatal InstituteScott M Norberg - National Cancer InstituteKim McClellan - Lawrence FoundationGeoffrey D Young - Florida International UniversityClint T Allen - National Cancer InstituteRecurrent Respiratory Papillomatosis Foundation
- Publication Details
- The Laryngoscope, Forthcoming
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- Recurrent Respiratory Papillomatosis Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:001662006600001
- Scopus ID
- 2-s2.0-105027896854
- Other Identifier
- 991022155329604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Otorhinolaryngology