Journal article
Red nucleus neurons of Bcl-2 over-expressing mice are protected from cell death induced by axotomy
Neuroreport, v 10(16), pp 3417-3421
08 Nov 1999
PMID: 10599855
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Bcl-2 proto-oncogene regulates apoptosis and prevents cell death. We studied the effect of Bcl-2 gene over-expression on the survival of axotomized red nucleus (RN) neurons after unilateral hemisection at cervical segment 4/5 (C4/5) in mice. Seventy-five percent of RN neurons survived in Bcl-2 over-expressing mice 1 or 2 months after surgery compared with only 55% of RN neurons in wild-type mice. However, Bcl-2 gene over-expression does not prevent lesion-induced shrinkage of RN neurons.
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Details
- Title
- Red nucleus neurons of Bcl-2 over-expressing mice are protected from cell death induced by axotomy
- Creators
- Linqiu Zhou - Dept of Neurobiology and Anatomy, MCP Hahnemann University, Philadelphia, PA 19129, USAT ConnorsDong ChenM MurrayA TesslerP KambinR Saavedra
- Publication Details
- Neuroreport, v 10(16), pp 3417-3421
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000083792700030
- Scopus ID
- 2-s2.0-0032717292
- Other Identifier
- 991019167323204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences