Journal article
Redefining bladder neck dose in low-dose-rate prostate brachytherapy–Can we improve urinary toxicity without impacting disease control?
Brachytherapy, v 23(1), pp 58-63
01 Jan 2024
PMID: 37821322
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We sought to assess the impact of bladder neck dose (BND) on patient reported urinary toxicity, and feasibility of relative urethral sparing technique in prostate brachytherapy (PB).
We retrospectively identified bladder neck as a point dose on post-implant CT scans in patients treated with 131Cs PB. Urinary symptoms were assessed through EPIC questionnaires. Patient cohorts were identified based on mean BND as a percentage of prescription dose with toxicity assessment at each time point.
In our cohort of 542 patients, BND was associated with clinically significant acute urinary symptoms and chronic symptoms, as patients receiving >70% of the prescription dose had significantly worse overall EPIC scores than patients receiving ≤70% of prescription dose. There was no difference in bDFS between patients receiving BND ≤70% (96% bDFS) and >70% (94% bDFS) at a median follow up of 57 months.
BND has a significant impact on both acute and chronic urinary symptoms, with reduced symptoms reported with BND <70% of prescription dose. With a median follow up of 4.7 years, excellent bDFS has thus far been achieved with relative urethral and bladder neck sparing. Utilizing this constraint should improve urinary symptoms without impacting disease control.
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Details
- Title
- Redefining bladder neck dose in low-dose-rate prostate brachytherapy–Can we improve urinary toxicity without impacting disease control?
- Creators
- Sean A. Koerner - UPMC Hillman Cancer CenterRonald M. Benoit - University of Pittsburgh School of MedicineSushil Beriwal - Allegheny Health NetworkRyan P. Smith - UPMC Hillman Cancer Center
- Publication Details
- Brachytherapy, v 23(1), pp 58-63
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:001171733300001
- Scopus ID
- 2-s2.0-85173788332
- Other Identifier
- 991021897363704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging