Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Reduced Cell Attachment to Poly(2-hydroxyethyl methacrylate)-Coated Ventricular Catheters in Vitro
Journal of biomedical materials research. Part B, Applied biomaterials, v 106(3), pp 1268-1279
20 Jun 2017
PMID: 28631360
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The majority of patients with hydrocephalus are dependent on ventriculoperitoneal shunts for diversion of excess cerebrospinal fluid. Unfortunately, these shunts are failure-prone and over half of all life-threatening pediatric failures are caused by obstruction of the ventricular catheter by the brain’s resident immune cells, reactive microglia and astrocytes. Poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels are widely used for biomedical implants. The extreme hydrophilicity of PHEMA confers resistance to protein fouling, making it a strong candidate coating for ventricular catheters. With the advent of initiated chemical vapor deposition (iCVD), a solvent-free coating technology that creates a polymer in thin film form on a substrate surface by introducing gaseous reactant species into a vacuum reactor, it is now possible to apply uniform polymer coatings on complex three-dimensional substrate surfaces. iCVD was utilized to coat commercially available ventricular catheters with PHEMA. The chemical structure was confirmed on catheter surfaces using Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). PHEMA coating morphology was characterized by scanning electron microscopy (SEM). Testing PHEMA-coated catheters against uncoated clinical-grade catheters in an in vitro hydrocephalus catheter bioreactor containing co-cultured astrocytes and microglia revealed significant reductions in cell attachment to PHEMA-coated catheters at both 17-day and 6-week time points.
Metrics
Details
- Title
- Reduced Cell Attachment to Poly(2-hydroxyethyl methacrylate)-Coated Ventricular Catheters in Vitro
- Creators
- Brian W. Hanak - Seattle Children's Research InstituteChia-Yun Hsieh - Drexel UniversityWilliam Donaldson - Seattle Children's Research InstituteSamuel R. Browd - Seattle Children's Research InstituteKenneth K.S. Lau - Drexel UniversityWilliam Shain - Seattle Children's Research Institute
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, v 106(3), pp 1268-1279
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000427068200034
- Scopus ID
- 2-s2.0-85021243015
- Other Identifier
- 991019168621804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials