Journal article
Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients
Proceedings of the National Academy of Sciences - PNAS, v 92(12), pp 5501-5505
06 Jun 1995
PMID: 7777538
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sézary syndrome (SzS), the leukemic form of cutaneous T-cell lymphoma, is characterized by clonal proliferation of CD4+ T cells and immune dysfunctions, raising the possibility of cytokine-related abnormalities. We previously described a decreased response to the growth-inhibitory effects of transforming growth factor type beta (TGF-beta) in SzS T cells accompanied by apparent loss of surface type II TGF-beta receptor (TGF beta RII). To specifically determine if defects exist in TGF beta RII protein expression and/or transport in SzS patients, we developed a sensitive flow cytometric method to detect TGF beta RII on the surface and intracellularly in the CD4+ T cells. Our results indicate that unlike normal CD4+ T cells, CD4+ T cells from 9 of 12 SzS patients expressed little, if any, surface TGF beta RII in response to mitogen stimulation. At the intracellular level, however, pools of TGF beta RII were comparable to those in normal CD4+ T cells. This indicates that defective trafficking of this inhibitory cytokine receptor may contribute significantly to the development of this disease.
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Details
- Title
- Reduced surface expression of transforming growth factor beta receptor type II in mitogen-activated T cells from Sézary patients
- Creators
- R J Capocasale - University of PennsylvaniaR J Lamb - University of PennsylvaniaE C Vonderheid - Drexel UniversityF E Fox - University of PennsylvaniaA H Rook - University of PennsylvaniaP C Nowell - University of PennsylvaniaJ S Moore - University of Pennsylvania
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 92(12), pp 5501-5505
- Publisher
- PNAS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1995RB80400051
- Scopus ID
- 2-s2.0-0029015704
- Other Identifier
- 991019183942204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology