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Journal article
Reducing Time to First Dose of Antibiotic: The Example of Asymptomatic Neonates Exposed to Chorioamnionitis
Pediatric quality & safety, v 6(3), pp e407-e407
01 May 2021
PMID: 33977195
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Time of medication delivery from the onset of illness is one factor that determines disease outcomes. In this study, we aimed to reduce the average time from admission to the first dose of antibiotic by at least 30% and increase the percentage of neonates receiving the first antibiotic dose within 1 hour of neonatal intensive care unit arrival to 50% over 12 months in asymptomatic neonates 34 weeks and older estimated gestational age with exposure to maternal chorioamnionitis as a sample population. Method: This study involved 135 infants 34 weeks and older gestational age exposed to chorioamnionitis. We documented the demographic characteristics of mothers and infants. We monitored time to the administration of the first dose of antibiotics through multiple plan-do-study-act cycles. We identified barriers to timely antibiotic administration and targeted them with multipronged interventions in plan-do-study-act cycles. Process measures were displayed monthly using X-bar/S control charts and P charts. We applied established rules for detecting a special cause. Results: We reduced the meantime to the first dose of antibiotics from 130 to 78 minutes (40% reduction). The percentage of infants who received the first antibiotic dose within 60 minutes rose from 5.8% to 36.3% during the study period. Special cause improvement was seen in all process measures. The most significant improvement seen was in the time to obtain a blood culture and the interval between intravenous access placement and antibiotic delivery. Conclusion: Multipronged interventions can help improve timely medication delivery to neonates in the neonatal intensive care unit in this example of infants exposed to chorioamnionitis.
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Details
- Title
- Reducing Time to First Dose of Antibiotic: The Example of Asymptomatic Neonates Exposed to Chorioamnionitis
- Creators
- Samuel Ajayi - Hendrick Medical CenterFolasade Kehinde - St. Christopher's Hospital for ChildrenDavid Cooperberg - Drexel UniversitySuzanne M. Touch - St. Christopher's Hospital for Children
- Publication Details
- Pediatric quality & safety, v 6(3), pp e407-e407
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000714179400010
- Scopus ID
- 2-s2.0-85150031789
- Other Identifier
- 991019169657404721
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- Web of Science research areas
- Pediatrics