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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Reducing neuropsychiatric symptoms in persons with dementia and associated burden in family caregivers using tailored activities: Design and methods of a randomized clinical trial
Contemporary clinical trials, v 49, pp 92-102
Jul 2016
PMID: 27339865
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Among over 5million people in the USA with dementia, neuropsychiatric symptoms (NPS) are almost universal, occurring across disease etiology and stage. If untreated, NPS can lead to significant morbidity and mortality including increased cost, distress, depression, and faster disease progression, as well as heightened burden on families. With few pharmacological solutions, identifying nonpharmacologic strategies is critical. We describe a randomized clinical trial, the Dementia Behavior Study, to test the efficacy of an activity program to reduce significant existing NPS and associated caregiver burden at 3 and 6months compared to a control group intervention. Occupational therapists deliver 8 in-home sessions over 3months to assess capabilities and interests of persons with dementia, home environments, and caregiver knowledge, and readiness from which activities are developed and families trained in their use. Families learn to modify activities for future declines and use strategies to address care challenges. The comparison group controls for time and attention and involves 8 in-home sessions delivered by health educators who provide dementia education, home safety recommendations, and advanced care planning. We are randomizing 250 racially diverse families (person with dementia and primary caregiver dyads) recruited from community-based social services, conferences and media announcements. The primary outcome is change in agitation/aggression at 3 and 6months. Secondary outcomes assess quality of life of persons with dementia, other behaviors, burden and confidence of caregivers, and cost and cost effectiveness. If benefits are supported, this activity intervention will provide a clinically meaningful approach to prevent, reduce, and manage NPS.
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Details
- Title
- Reducing neuropsychiatric symptoms in persons with dementia and associated burden in family caregivers using tailored activities: Design and methods of a randomized clinical trial
- Creators
- Laura N Gitlin - Johns Hopkins UniversityCatherine Verrier Piersol - Johns Hopkins UniversityNancy Hodgson - Johns Hopkins UniversityKatherine Marx - Johns Hopkins UniversityDavid L Roth - Johns Hopkins UniversityDeidre Johnston - Johns Hopkins UniversityQuincy Samus - Johns Hopkins UniversityLaura Pizzi - Johns Hopkins UniversityEric Jutkowitz - Johns Hopkins UniversityConstantine G Lyketsos - Johns Hopkins University
- Publication Details
- Contemporary clinical trials, v 49, pp 92-102
- Publisher
- Elsevier
- Grant note
- R01 AG041781 / NIA NIH HHS P50 AG005146 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Nursing and Health Professions; Drexel University
- Web of Science ID
- WOS:000381543800013
- Scopus ID
- 2-s2.0-84976345027
- Other Identifier
- 991020100184504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy