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Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children
Journal article   Peer reviewed

Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children

D M Stoff, L Pollock, B Vitiello, D Behar and W H Bridger
Neuropsychopharmacology (New York, N.Y.), v 1(1), pp 55-62
01 Dec 1987
DOI: https://doi.org/10.1016/0893-133X(87)90010-8
PMID: 2855302
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Binding characteristics of tritiated imipramine on blood platelets were determined in daytime hospitalized prepubertal children who had mixed diagnoses of conduct disorder (CD) plus attention deficit disorder hyperactivity (ADDH) and in inpatient adolescents who had a history of aggressive behavior. The number of (3H)-imipramine maximal binding sites (Bmax) was significantly lower in the prepubertal patient group of CD plus ADDH; the dissociation constant (Kd) was not significantly different. There were significant negative correlations between Bmax and the Externalizing or Aggressive factors of the Child Behavior Checklist when the CD plus ADDH prepubertal patients were combined with their matched controls and within the adolescent inpatient group. We propose that a decreased platelet imipramine binding Bmax value, as an index of disturbed presynaptic serotonergic activity, is not specific to depression and may be used as a biologic marker for the lack of behavioral constraint in heterogeneous. populations of psychiatric patients.

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Web of Science research areas
Neurosciences
Pharmacology & Pharmacy
Psychiatry
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