Journal article
Reduction of Enhanced Mammary Carcinogenesis in LA/N-cp (Corpulent) Rats by Energy Restriction
Proceedings of the Society for Experimental Biology and Medicine, v 196(4), pp 381-384
Apr 1991
PMID: 1901169
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract
Restriction of energy intake significantly reduces mammary tumorigenesis in normal rats exposed to carcinogens. Genetically obese LA/N-cp (corpulent) female rats were given 7,12-dimethylbenz[a]anthracene and fed purified diets ad libitum or restricted to 60% of the ad libitum caloric intake. Phenotypically lean littermates were also fed ad libitum. Obese animals developed large mammary tumors more rapidly than genetically normal rats so that 100% of the animals had tumors in less than 16 weeks. Only 21% of the lean animals developed tumors; the energy restricted obese animals had a tumor incidence of 27%. Although obese rats fed the restricted diet weighed significantly less than those fed ad libitum, percent body fat was not reduced, indicating that lean tissue was affected more. Obese animals were markedly hyperinsulinemic (1003 ± 193 microunits/ml) and energy restriction reduced this to 328 ± 41; the lean animals had insulin levels of 12 ± 2. Tumor-bearing rats had higher insulin levels than rats without tumors. These data suggest that body fatness is not directly associated with risk of carcinogenesis. Lean body mass, adipose tissue mass, and their interaction with insulin in its capacity as a growth factor rather than body fatness per se may be determinants of tumor promotion.
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Details
- Title
- Reduction of Enhanced Mammary Carcinogenesis in LA/N-cp (Corpulent) Rats by Energy Restriction
- Creators
- David M. Klurfeld - The Wistar InstituteLisa M. Lloyd - The Wistar InstituteCarrie B. Welch - The Wistar InstituteMatthew J. Davis - The Wistar InstituteOrien L. Tulp - The Wistar InstituteDavid Kritchevsky - The Wistar InstituteMartha J Davis - Physician Assistant
- Publication Details
- Proceedings of the Society for Experimental Biology and Medicine, v 196(4), pp 381-384
- Publisher
- SAGE Publications
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physician Assistant
- Web of Science ID
- WOS:A1991FE55900003
- Scopus ID
- 2-s2.0-0025780434
- Other Identifier
- 991019173765404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental