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Journal article
Reduction of left ventricular longitudinal global and segmental systolic functions in patients with hypertrophic cardiomyopathy: Study of two-dimensional tissue motion annular displacement
Experimental and therapeutic medicine, v 7(6), pp 1457-1464
12 Mar 2014
PMID: 24926326
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The early detection of abnormal left ventricular systolic functions in patients with hypertrophic cardiomyopathy (HCM) remains a challenge. The aim of this study was to identify a novel method for the assessment of left ventricular systolic function in patients with HCM. A total of 65 patients with HCM were included in this study. The patients were divided into obstructive HCM (HOCM; 16 cases) and non-obstructive HCM (NOHCM; 49 cases) groups. The healthy control group comprised 48 participants. Two-dimensional (2D) speckle-tracking technology was used to measure the left ventricular global and segmental longitudinal strains and mitral annular displacement (MADs). Compared with healthy control group, the six segmental strains and the global strain of the left ventricle (LS
global
) increased while six segmental MADs and MAD
global
of the mitral annulus decreased in the HOCM and NOHCM groups (P<0.05). In addition, the six segmental MADs of the mitral annulus were significantly negatively correlated with the six segmental strains of the left ventricle (r=−0.744 to −0.647, P<0.001). MAD
global
was significantly negatively correlated with LS
global
(r=−0.857, P<0.001). The tissue motion annular displacement (TMAD) at the midpoint was significantly negatively correlated with LS
global
(r=−0.871, P<0.001). The 2D TMAD technique of measuring MAD was feasible and practically approachable for rapidly evaluating the left ventricular longitudinal global and segmental systolic functions of patients with HCM.
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Details
- Title
- Reduction of left ventricular longitudinal global and segmental systolic functions in patients with hypertrophic cardiomyopathy: Study of two-dimensional tissue motion annular displacement
- Creators
- LIWEN Liu - Air Force Medical UniversitySHENGJUN Tuo - Air Force Medical UniversityJIANLEI Zhang - Air Force Medical UniversityLEI Zuo - Air Force Medical UniversityFANG Liu - Air Force Medical UniversityLILI Hao - Air Force Medical UniversityYANDAN Sun - Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710032, P.R. China Department of Ultrasound, Yan’an People’s Hospital, Yan’an, Shaanxi 716000, P.R. China Department of Cardiology, The Heart Center, St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USALIPING Yang - Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710032, P.R. China Department of Ultrasound, Yan’an People’s Hospital, Yan’an, Shaanxi 716000, P.R. China Department of Cardiology, The Heart Center, St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USAHONG Shao - Air Force Medical UniversityWEI QI - Air Force Medical UniversityXIAODONG Zhou - Air Force Medical UniversitySHUPING GE - St. Christopher's Hospital for Children
- Publication Details
- Experimental and therapeutic medicine, v 7(6), pp 1457-1464
- Publisher
- D.A. Spandidos
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000336555100003
- Scopus ID
- 2-s2.0-84898440537
- Other Identifier
- 991019167333404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental