Journal article
Refinement of the Iddm4 Diabetes Susceptibility Locus Reveals TCRVβ4 as a Candidate Gene
Annals of the New York Academy of Sciences, v 1103(1), pp 128-131
Apr 2007
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Abstract
:
Iddm4 is a dominant non‐major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. In congenic MHC‐identical normal WF rats, Iddm4d sensitively and specifically predicts induced diabetes. We report a new diabetes‐susceptible subcongenic line that carries Iddm4 in a < 2.6 megabase interval. Candidate genes include the T cell receptor β chain variable (TCRVβ) family. We found that TCRVβ4 in WF rats contains a stop codon, whereas 5/5 diabetes‐susceptible rat strains express TCRVβ4. We conclude that Iddm4‐mediated diabetes resistance in rats may be due to a recessive protective mutation in TCRVβ4.
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Details
- Title
- Refinement of the Iddm4 Diabetes Susceptibility Locus Reveals TCRVβ4 as a Candidate Gene
- Creators
- ELIZABETH P BLANKENHORNCHERYL DESCIPIOLUCY RODEMICHLAURA CORTJEAN H LEIFDALE L GREINERJOHN P MORDES
- Publication Details
- Annals of the New York Academy of Sciences, v 1103(1), pp 128-131
- Publisher
- Blackwell Publishing Inc; Malden, USA
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; [Retired Faculty]
- Web of Science ID
- WOS:000246646400014
- Scopus ID
- 2-s2.0-34249060004
- Other Identifier
- 991014878447204721
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- Web of Science research areas
- Medicine, Research & Experimental