Logo image
Back
Regional Variation in Canal Volume of the Human Tibial Cortex
Journal article   Peer reviewed

Regional Variation in Canal Volume of the Human Tibial Cortex

Naomi A. Hampson, Karl J. Jepsen, Surya R. Kalidindi, G. Felipe Duarte and Haviva M Goldman
The FASEB journal, v 25(S1), pp 488.8-488.8
Apr 2011
DOI: https://doi.org/10.1096/fasebj.25.1_supplement.488.8

Abstract

The microstructural organization of bone within the human tibial cortex plays an important role in its functional adaptation to bending loads, compensatory with variation in cross‐sectional shape. We aimed to investigate regional variation in volumetric porosity (percent canal volume, or %CV) of the cortical bone of the human tibia cortex at two clinically relevant sites (38% and 66% of total tibia length). 2.5 mm cross‐sections of 10 tibiae (6 male, 4 female, age 37 +/− 8 yrs) from each site were radially sectioned into 6 wedges and imaged using a Skyscan 1172 microCT at a 5 μm resolution. The %CV of the cortical bone was determined using Skyscan's CT Analyzer for each location. At the 38% and 66% locations, the anterior segment was significantly (p < 0.05) more porous than all medial and lateral segments. At the 66% location, the posterior segment was significantly more porous than antero‐medial and postero‐lateral segments. The higher porosity values noted anteriorly (and to a lesser degree, posteriorly) may reflect higher remodeling rates in these cortices, and relate to the A‐P orientation of the axis of greatest bending rigidity. Such variability in porosity is likely to have an effect on volumetric density. Hence we will also report on ongoing correlative investigations between microCT and pQCT generated datasets that will be used to generate a larger understanding of the effects of the regional variations observed. Grant Funding Source: DOD (DAMD 17‐01‐1‐0806)

Metrics

7 Record Views

Details

Logo image