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Journal article
Regional biomechanical imaging of liver cancer cells
Journal of Cancer, v 10(19), pp 4481-4487
01 Jan 2019
PMID: 31528212
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Liver cancer is one of the leading cancers, especially in developing countries. Understanding the biomechanical properties of the liver cancer cells can not only help to elucidate the mechanisms behind the cancer progression, but also provide important information for diagnosis and treatment. At the cellular level, we used well-established atomic force microscopy (AFM) techniques to characterize the heterogeneity of mechanical properties of two different types of human liver cancer cells and a normal liver cell line. Stiffness maps with a resolution of 128x128 were acquired for each cell. The distributions of the indentation moduli of the cells showed significant differences between cancerous cells and healthy controls. Significantly, the variability was even greater amongst different types of cancerous cells. Fitting of the histogram of the effective moduli using a normal distribution function showed the Bel7402 cells were stiffer than the normal cells while HepG2 cells were softer. Morphological analysis of the cell structures also showed a higher cytoskeleton content among the cancerous cells. Results provided a foundation for applying knowledge of cell stiffness heterogeneity to search for tissue-level, early-stage indicators of liver cancer.
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Details
- Title
- Regional biomechanical imaging of liver cancer cells
- Creators
- Weiwei Pei - Soochow UniversityJiayao Chen - Soochow UniversityChao Wang - Drexel UniversitySuhao Qiu - Shanghai Jiao Tong UniversityJianfeng Zeng - Soochow UniversityMingyuan Gao - Soochow UniversityBin Zhou - Fifth Affiliated Hospital of Sun Yat-sen UniversityDan Li - Fifth Affiliated Hospital of Sun Yat-sen UniversityMichael S. Sacks - The University of Texas at AustinLin Han - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USAHong Shan - Fifth Affiliated Hospital of Sun Yat-sen UniversityWentao Hu - Soochow UniversityYuan Feng - Shanghai Jiao Tong UniversityGuangming Zhou - Soochow University
- Publication Details
- Journal of Cancer, v 10(19), pp 4481-4487
- Publisher
- Ivyspring Int Publ
- Number of pages
- 7
- Grant note
- 16KJB460018 / Jiangsu Province Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) K511701515 / Scientific Research Foundation for the Returned Overseas Chinese Scholars 2015J007 / Zhuhai Medical and Health Science and Technology Program, State Education Ministry 61503267 / National Natural Science Foundation; National Natural Science Foundation of China (NSFC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000484111000005
- Scopus ID
- 2-s2.0-85071869545
- Other Identifier
- 991019169901904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology