Journal article
Regional differences in substance P-like immunoreactivity in the striatum correlate with levels of pre-protachykinin mRNA
Neuroscience letters, v 96(1)
1989
PMID: 2467230
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The distribution of neurons containing the messenger RNA encoding preprotachykinin, the precursor of the neuropeptides substance P and K, was examined in the striatum of the rat. The large majority of cells densely labelled by in situ hybridization histochemistry (using a
35S-radiolabelled RNA probe complementary of the beta-preprotachykinin mRNA) were located within the boundaries of areas of dense [
3H]naloxone binding which delineate the striosomes, a striatal compartment distinct from the surrounding matrix with respect to its inputs, outputs and neurochemical content. In view of previous immunohistochemical data, the results suggest that tachykinin-containing neurons of the striosomes have a higher rate of tachykinin synthesis than those neurons located in the surrounding striatal matrix.
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Details
- Title
- Regional differences in substance P-like immunoreactivity in the striatum correlate with levels of pre-protachykinin mRNA
- Creators
- Marie-Francoise Chesselet - Drexel UniversityElaine Robbins - Woman's Medical College of PennsylvaniaEli Wr Robbins - Interior Design
- Publication Details
- Neuroscience letters, v 96(1)
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Interior Design
- Web of Science ID
- WOS:A1989R606500009
- Scopus ID
- 2-s2.0-0024495707
- Other Identifier
- 991019184212404721
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- Web of Science research areas
- Neurosciences