Journal article
Regional effects of aortomyoplasty in acute ischemia
The Annals of thoracic surgery, v 61(1), pp 426-429
1996
PMID: 8561620
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aortomyoplasty is a technique for achieving autogenous diastolic counterpulsation. This experiment was designed to determine if aortomyoplasty using conditioned latissimus dorsi muscle could improve regional myocardial function during coronary ischemia.
Six mongrel dogs underwent a staged operation in which the left latissimus dorsi was conditioned in situ for 4 weeks, then wrapped around the descending aorta and stimulated during diastole with each cardiac contraction. Regional ischemia was caused by occlusion of the left anterior descending coronary artery. Regional function was measured with sonomicrometry in the region of ischemia and in a control area. An intraaortic balloon pump was inserted for comparison with aortomyoplasty performance.
Coronary artery occlusion caused a significant decrease in the percentage of regional shortening (14.2 ± 7.9 to −2.2 ± 4.0;
p = 0.001) and thickening (11.9 ± 4.6 to −5.8 ± 3.3;
p < 0.001). Aortomyoplasty improved regional motion in both percentage shortening (−2.2 ± 4.0 to 2.3 ± 3.7;
p = 0.008) and thickening (−5.8 ± 3.3 to 2.8 ± 1.9;
p < 0.001). The intraaortic balloon pump also improved percentage shortening (−3.7 ± 2.0 to 0.7 ± 1.9;
p = 0.01) and thickening (±5.0 ± 2.8 to 2.4 ± 3.8;
p < 0.001), and was not significantly different than aortomyoplasty.
These data show that aortomyoplasty has beneficial effects on ischemic left ventricular contractility, and may therefore be useful for treating inoperable coronary artery disease.
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Details
- Title
- Regional effects of aortomyoplasty in acute ischemia
- Creators
- John C. Cardone - Allegheny General HospitalPyongsoo D. YoonDennis R. TrumbleJames A. Magovern
- Publication Details
- The Annals of thoracic surgery, v 61(1), pp 426-429
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:A1996TR81800123
- Scopus ID
- 2-s2.0-0030063713
- Other Identifier
- 991019168992304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery