Journal article
Regulation of CXCR4 expression and impact on HIV-1 infection by the mu-opioid agonist DAMGO in a bone marrow progenitor cell line model
Journal of neurovirology, Vol.13, pp.30-30
01 Jan 2007
Abstract
Several studies now suggest that opioids act as a co-factor in enhancing susceptibility to HIV-1 infection in immune cell populations as well as modulating innate, humoral, and cell-mediated immunity. Studies have also shown that under chronic exposure to mu opioid receptor ligands like morphine there is an increased detection in the amount of HIV-1 long terminal repeat (LTR) DNA in cells of the monocyte-macrophage lineage. CD34+/CD38 - progenitor cells within the bone marrow are retractile to HIV-1 infection, probably due to their low level expression of HIV-1 co-receptors, CXCR4 and CCR5. We have previously shown that the human CD34+/CD38+ TF-1 erythromyeloid progenitor cell line can be utilized as a model to study the differentiation process of hematopoietic progenitor cells and how this differentiation process effects the cell surface expression of the HIV-1 receptor and co-receptors and HIV-1 susceptibility. Given these observations, studies have been initiated to identify the presence of the mu opioid receptor on the TF-1 bone marrow progenitor cell line. Studies have also been initiated to determine the functional relevance of this receptor in altering HIV-1 co-receptor expression, susceptibility to HIV-1 infection, impact on HIV-1 LTR activity, and impact on HIV-1 replication during chronic opioid exposure.
Metrics
1 Record Views
Details
- Title
- Regulation of CXCR4 expression and impact on HIV-1 infection by the mu-opioid agonist DAMGO in a bone marrow progenitor cell line model
- Creators
- A BanerjeeA AlexakiV PirroneB WigdahlM Nonnemacher
- Publication Details
- Journal of neurovirology, Vol.13, pp.30-30
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Identifiers
- 991019170455104721