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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Regulation of DNA Replication through Natural Impediments in the Eukaryotic Genome
Genes, v 8(3), p98
01 Mar 2017
PMCID: PMC5368702
PMID: 28272375
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
All living organisms need to duplicate their genetic information while protecting it from unwanted mutations, which can lead to genetic disorders and cancer development. Inaccuracies during DNA replication are the major cause of genomic instability, as replication forks are prone to stalling and collapse, resulting in DNA damage. The presence of exogenous DNA damaging agents as well as endogenous difficult-to-replicate DNA regions containing DNA-protein complexes, repetitive DNA, secondary DNA structures, or transcribing RNA polymerases, increases the risk of genomic instability and thus threatens cell survival. Therefore, understanding the cellular mechanisms required to preserve the genetic information during S phase is of paramount importance. In this review, we will discuss our current understanding of how cells cope with these natural impediments in order to prevent DNA damage and genomic instability during DNA replication.
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Details
- Title
- Regulation of DNA Replication through Natural Impediments in the Eukaryotic Genome
- Creators
- Mariana C. Gadaleta - Drexel UniversityEishi Noguchi - Drexel University
- Publication Details
- Genes, v 8(3), p98
- Publisher
- Mdpi
- Number of pages
- 28
- Grant note
- R01GM077604 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) GM077604 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Aging Initiative at Drexel University College of Medicine
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000399058500014
- Scopus ID
- 2-s2.0-85015189995
- Other Identifier
- 991019169555404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity