Journal article
Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions
Molecular and cellular neurosciences, v 26(1)
2004
PMID: 15121177
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Axonal regeneration in the adult CNS is limited by the presence of several inhibitory proteins associated with myelin. Nogo-A, a myelin-associated inhibitor, is responsible for axonal outgrowth inhibition in vivo and in vitro. Here we study the onset and maturation of Nogo-A and Nogo receptor in the entorhino-hippocampal formation of developing and adult mice. We also provide evidence that Nogo-A does not inhibit embryonic hippocampal neurons, in contrast to other cell types such as cerebellar granule cells. Our results also show that Nogo and Nogo receptor mRNA are expressed in the adult by both principal and local-circuit hippocampal neurons, and that after lesion, Nogo-A is also transiently expressed by a subset of reactive astrocytes. Furthermore, we analyzed their regulation after kainic acid (KA) treatment and in response to the transection of the entorhino-hippocampal connection. We found that Nogo-A and Nogo receptor are differentially regulated after kainic acid or perforant pathway lesions. Lastly, we show that the regenerative potential of lesioned entorhino-hippocampal organotypic slice co-cultures is increased after blockage of Nogo-A with two IN-1 blocking antibodies. In conclusion, our results show that Nogo and its receptor might play key roles during development of hippocampal connections and that they are implicated in neuronal plasticity in the adult.
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Details
- Title
- Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions
- Creators
- Ana Mingorance - Universitat de BarcelonaXavier Fontana - Universitat de BarcelonaMarta Solé - Universitat de BarcelonaFerran Burgaya - Universitat de BarcelonaJesús M. Ureña - Universitat de BarcelonaFelicia Y.H. Teng - Institute of Molecular and Cell BiologyBor Luen Tang - Institute of Molecular and Cell BiologyDavid Hunt - University College LondonPatrick N. Anderson - Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UKJohn R. Bethea - University of MiamiMartin E. Schwab - Department of Neuromorphology, Brain Research Institute, University and ETH, Zurich, SwitzerlandEduardo Soriano - Universitat de BarcelonaJosé A. del Rı́o - Universitat de Barcelona
- Publication Details
- Molecular and cellular neurosciences, v 26(1)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000221443800004
- Scopus ID
- 2-s2.0-2342593377
- Other Identifier
- 991020099749204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences