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Journal article
Regulation of Protein Levels in Subcellular Domains through mRNA Transport and Localized Translation
Molecular & cellular proteomics, v 9(5), pp 952-962
01 May 2010
PMID: 20167945
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Localized protein synthesis is increasingly recognized as a means for polarized cells to modulate protein levels in subcellular regions and the distal reaches of their cytoplasm. The axonal and dendritic processes of neurons represent functional domains of cytoplasm that can be separated from their cell body by vast distances. This separation provides a biological setting where the cell uses locally synthesized proteins to both autonomously respond to stimuli and to retrogradely signal the cell body of events occurring is this distal environment. Other cell types undoubtedly take advantage of this localized mechanism, but these have not proven as amenable for isolation of functional subcellular domains. Consequently, neurons have provided an appealing experimental platform for study of mRNA transport and localized protein synthesis. Molecular biology approaches have shown both the population of mRNAs that can localize into axons and dendrites and an unexpectedly complex regulation of their transport into these processes. Several lines of evidence point to similar complexities and specificity for regulation of mRNA translation at subcellular sites. Proteomics studies are beginning to provide a comprehensive view of the protein constituents of subcellular domains in neurons and other cell types. However, these have currently fallen short of dissecting temporal regulation of new protein synthesis in subcellular sites and mechanisms used to ferry mRNAs to these sites.
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Details
- Title
- Regulation of Protein Levels in Subcellular Domains through mRNA Transport and Localized Translation
- Creators
- Dianna E. Willis - Burke Medical Research InstituteJeffery L. Twiss - Drexel University
- Publication Details
- Molecular & cellular proteomics, v 9(5), pp 952-962
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000279396700017
- Scopus ID
- 2-s2.0-77951848688
- Other Identifier
- 991021892107104721
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- Web of Science research areas
- Biochemical Research Methods