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Journal article
Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
Microorganisms (Basel), v 9(10), p2026
01 Oct 2021
PMID: 34683347
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which regulates the expression of vancomycin resistance in VRE. VanS is a sensor histidine kinase that detects vancomycin and in turn activates VanR; VanR is a response regulator that, when activated, directs expression of vancomycin-resistance genes. This review of VanRS examines how the expression of vancomycin resistance is regulated, and provides an update on one of the field's most pressing questions: How does VanS sense vancomycin?
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Details
- Title
- Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System
- Creators
- Alexandra A. Guffey - Drexel UniversityPatrick J. Loll - Drexel University
- Publication Details
- Microorganisms (Basel), v 9(10), p2026
- Publisher
- Mdpi
- Number of pages
- 26
- Grant note
- 1R01AI148679 / NIH-NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000712851200001
- Scopus ID
- 2-s2.0-85115805562
- Other Identifier
- 991019170121504721
UN Sustainable Development Goals (SDGs)
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- Web of Science research areas
- Microbiology