Journal article
Regulation of graft‐versus‐host‐reaction by Mlsa‐reactive donor T cells
European journal of immunology, v 22(8), pp 1967-1973
Aug 1992
PMID: 1639099
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Abstract
Injection of A/J splenocytes (H‐2Dd, Mlsc) into unirradiated (A/J x CBA)F1 (BAF1) host mice (H‐2Dd/k, Mlsd) results in an acute suppressive graft‐vs. ‐host reaction (GVHR), characterized by immune dysfunction and appreciable donor cell engraftment; injection of the CBA/J parent (H‐2Dk, Mlsd), which recognizes no Mls disparity in the host, results in little or no GVHR. Furthermore, the Mlsa‐reactive Vβ6 and Vβ8.1 T cell subsets in A/J T cells expand significantly in the GVHR host. Finally, depletion of Vβ6+ and Vβ8.1+ from the A/J population abrogates the proliferative response to BAF1 in vitro and the development of GVHR in vivo. Thus, the response to Mls determinants can contribute to the generation of a GVHR.
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Details
- Title
- Regulation of graft‐versus‐host‐reaction by Mlsa‐reactive donor T cells
- Creators
- Satish C. Muluk - National Institutes of HealthFrances T. Hakim - National Institutes of HealthGene M. Shearer - National Institutes of Health
- Publication Details
- European journal of immunology, v 22(8), pp 1967-1973
- Publisher
- WILEY‐VCH Verlag GmbH; DEERFIELD BEACH
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:A1992JH91900002
- Scopus ID
- 2-s2.0-0026772844
- Other Identifier
- 991021944494704721
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- Web of Science research areas
- Immunology