Journal article
Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction
Journal of neuroimmune pharmacology, v 6(4), pp 466-476
Dec 2011
PMID: 21465240
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The heavy chain subunit of ferritin (FHC), a ubiquitous protein best known for its iron-sequestering activity as part of the ferritin complex, has recently been described as a novel inhibitor of signaling through the chemokine receptor CXCR4. Levels of FHC as well as its effects on CXCR4 activation increase in cortical neurons exposed to mu-opioid receptor agonists such as morphine, an effect likely specific to neurons. Major actions of CXCR4 signaling in the mature brain include a promotion of neurogenesis, activation of pro-survival signals, and modulation of excitotoxic pathways; thus FHC up-regulation may contribute to the neuronal dysfunction often associated with opiate drug abuse. This review summarizes our knowledge of neuronal CXCR4 function, its regulation by opiates and the role of FHC in this process, and known mechanisms controlling FHC production. We speculate on the mechanism involved in FHC regulation by opiates, and offer FHC as a new target in opioid-induced neuropathology.
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Details
- Title
- Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction
- Creators
- Anna Cook Abt - Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 N. 15Olimpia Meucci - Department of Pharmacology and Physiology, Drexel University College of Medicine, 245 N. 15
- Publication Details
- Journal of neuroimmune pharmacology, v 6(4), pp 466-476
- Publisher
- Springer Nature
- Grant note
- R01 DA019808 || DA / National Institute on Drug Abuse : NIDA R01 DA015014 || DA / National Institute on Drug Abuse : NIDA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000296651500004
- Scopus ID
- 2-s2.0-81355138976
- Other Identifier
- 991014878203404721
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- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy