Journal article
Relapse and Rehospitalization During Maintenance Treatment of Schizophrenia: The Effects of Dose Reduction and Family Treatment
Archives of general psychiatry, Vol.54(5), pp.453-463
01 May 1997
PMID: 9152099
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Previous studies have examined dose reduction and family treatment in schizophrenia, but none has examined their interaction. This study assessed the impact of dose reduction of antipsychotic medication and family treatment on relapse and rehospitalization during maintenance treatment. METHODS: Subjects were 313 male and female outpatients at 5 centers with a DSM-III-R diagnosis of schizophrenia or schizoaffective disorder. In a 3X2 design, subjects were randomized to 1 of 3 medication strategies using fluphenazine decanoate under double-blind conditions: continuous moderate dose (standard) (12.5-50 mg every 2 weeks); continuous low dose (2.5-10 mg every 2 weeks); or targeted, early intervention (fluphenazine only when symptomatic). Subjects also were randomized to 1 of 2 family treatment strategies (supportive or applied). Supportive family management involved monthly group meetings. The more intensive applied family management involved monthly group meetings and home visits where communication and problem-solving skills were taught. Patients and families were treated and assessed for 2 years. RESULTS: Both continuous low-dose and targeted treatment increased use of rescue medication and relapse; only targeted treatment increased rehospitalization. This pattern was consistent across both family treatments; there were no differences between family treatments. CONCLUSIONS: These findings reaffirm the value of antipsychotic medication in preventing relapse and rehospitalization. The absence of family treatment differences may be because both conditions engaged families.
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Details
- Title
- Relapse and Rehospitalization During Maintenance Treatment of Schizophrenia: The Effects of Dose Reduction and Family Treatment
- Creators
- Nina R Schooler - Western Psychiatric Institute and Clinic, Pittsburgh PA 15213, USA.Samuel J KeithJoanne B SevereSusan M MatthewsAlan S BellackIra D GlickWilliam A HargreavesJohn M KanePhilip T NinanAllen FrancesMarc JacobsJeffrey A LiebermanRosalind ManceGeorge M SimpsonMargaret G WoernerMadelyn Rachel Jacobs - College of Arts and Sciences (1990-)
- Publication Details
- Archives of general psychiatry, Vol.54(5), pp.453-463
- Publisher
- American Medical Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Arts and Sciences
- Identifiers
- 991019168253604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry