Journal article
Relationship between Sustained Disability Progression and Functional System Scores in Relapsing-Remitting Multiple Sclerosis: Analysis of Placebo Data from Four Randomized Clinical Trials
Neuroepidemiology, v 44(1)
01 Jan 2015
PMID: 25634764
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: The Expanded Disability Status Scale (EDSS), based on different functional system scores (FSS), remains the most frequently used disability assessment in relapsing-remitting multiple sclerosis (RRMS). In this analysis, we evaluated the relationship between sustained disability progression, measured by EDSS, and simultaneous changes in individual FSS domains. Methods: A post hoc analysis was performed on data from placebo-treated RRMS patients from four large, randomized, multicenter, phase 3 clinical trials. Sustained disability progression was defined as a EDSS score increase over a or >= 3- or >= 6-month period. Simultaneous sustained disability progression and worsening of individual FSS domains was analyzed. Results: The majority of patients experienced sustained disability progression and simultaneous worsening of FSS domain, with >= 1-point worsening in the pyramidal domain being most frequently associated with sustained disability progression (in 31-51% of patients), followed by 1-point worsening in the cerebellar (35-41% of patients) and sensory (31-45% of patients) domains. Conclusion: The key FSS components correlating with sustained disability progression, measured by EDSS, appear to be pyramidal, cerebellar, and sensory. In this analysis, the simultaneous worsening of consistent FSS domains confirms the validity and reliability of the use of sustained EDSS progression as a measure of disability progression. (C) 2015 S. Karger AG, Basel
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Details
- Title
- Relationship between Sustained Disability Progression and Functional System Scores in Relapsing-Remitting Multiple Sclerosis: Analysis of Placebo Data from Four Randomized Clinical Trials
- Creators
- Thomas Scott - Allegheny General HospitalPing Wang - Biogen Idec Inc, Cambridge, MA USAXiaojun You - Biogen Idec Inc, Cambridge, MA USAMonica Mann - Biogen Idec Inc, Cambridge, MA USABjorn Sperling - Biogen Idec Inc, Cambridge, MA USA
- Publication Details
- Neuroepidemiology, v 44(1)
- Publisher
- Karger
- Number of pages
- 8
- Grant note
- Biogen Idec Inc.; Biogen
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000350940200003
- Scopus ID
- 2-s2.0-84921902527
- Other Identifier
- 991019167457504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Public, Environmental & Occupational Health