Journal article
Relationship between incident cardiovascular disease and quality of life after a breast cancer diagnosis
Journal of cancer survivorship
06 Feb 2025
PMID: 39909978
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Breast cancer survivors are at risk for both poor quality of life (QoL) and cardiovascular disease (CVD). This study examines whether incident CVD after breast cancer independently predicts QoL.
Using data from the Women's Health Initiative, we included women who were diagnosed with invasive breast cancer during follow-up and free of prevalent CVD prior to breast cancer. CVD was defined as adjudicated coronary heart disease, heart failure, or stroke. Physical and mental QoL, measured by the SF-36 Physical and Mental Component Scores (PCS and MCS, respectively), were recorded after breast cancer. Poor PCS and MCS were defined as scores < 40. We used adjusted time-dependent Cox proportional hazards models, accounting for time to CVD.
Among 2912 BC survivors (mean age at BC diagnosis = 67), 1094 (37.6%) and 313 (10.7%) women had a post-breast cancer PCS and MCS score < 40, respectively, at a median of 2.5 years. A higher proportion of women had poor PCS scores post-BC (37.5% vs. 19.2%, P < 0.001) but not MCS (10.4% vs. 8.2%, P = 0.10). After adjustment for key covariates, incident CVD was associated with a 1.95-fold (95% CI 1.42, 2.67) greater risk of poor PCS scores (P < 0.001), but was not associated with poor MCS (HR 1.23, 95% CI 0.57, 2.65, P = 0.59)).
Incident CVD after breast cancer was associated with poor physical QoL but not mental QoL.
This study highlights the importance of regular assessments of QoL and need for strategies to improve physical QoL in breast cancer survivors with CVD.
Metrics
Details
- Title
- Relationship between incident cardiovascular disease and quality of life after a breast cancer diagnosis
- Creators
- Alexi Vasbinder - University of WashingtonElena Wadden - University of WashingtonRichard K Cheng - University of WashingtonAna Barac - Inova Design Solutions (United Kingdom)Christopher R Friese - University of MichiganYangbo Sun - University of Tennessee Health Science CenterAladdin H Shadyab - Human Longevity (United States)Longjian Liu - Drexel UniversityLisa Warsinger Martin - George Washington UniversityMarcia Stefanick - Stanford UniversityMichael S Simon - The Barbara Ann Karmanos Cancer InstituteKerryn Reding - University of Washington
- Publication Details
- Journal of cancer survivorship
- Publisher
- SPRINGER; NEW YORK
- Number of pages
- 10
- Grant note
- National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services: 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005
The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005. For a list of WHI investigators, please visit https://www-whi-org.s3.us-west-2.amazonaws.com/wp-content/uploads/WHI-Investigator-Short-List.pdf.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:001415966700001
- Scopus ID
- 2-s2.0-85217653276
- Other Identifier
- 991022026256804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Social Sciences, Biomedical