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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia
Prostaglandins, leukotrienes and essential fatty acids, v 146, pp 11-18
Jul 2019
PMID: 31186149
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Chronic inflammation is one of the hallmarks of sickle cell disease (SCD). We have previously demonstrated that the inflammatory biomarker hs-CRP positively correlated with vaso-occlusive pain in SCD.•In children with SCD, ratios of pro-inflammatory arachidonic acid (AA) to anti-inflammatory docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids are increased in red cell phospholipids due to a relative decrease in omega-3 fatty acids.•A relative deficiency of DHA and EPA correlates positively with hs-CRP in children with SCD.•A relative deficiency of DHA and EPA increases with age in children with SCD.
Inflammation and vaso-occlusion play key roles in Sickle Cell Disease (SCD) pathophysiology. Lipoxygenase products of the omega-3 fatty acids (O3FAs), docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, are potent anti-inflammatory mediators modulating pain. O3FAs decrease episodes of vaso-occlusion in SCD.
We assessed erythrocyte fatty acid composition in two major cell membrane phospholipids, phosphatidylcholine and phosphatidylethanolamine, in children with SCD HbSS-disease (n = 38) and age/race-matched HbAA-controls (n = 18). Ratio of pro-inflammatory arachidonic acid (AA) to anti-inflammatory DHA and EPA (FA-Ratio), and its relationship to hs-CRP were evaluated.
FA-Ratios were increased in both phosphatidylcholine and phosphatidylethanolamine in HbSS compared to controls. Correlations were noted in HbSS subjects between hs-CRP and FA-Ratios (p = 0.011). FA-Ratios increased with age (p = 0.0007) due to an increase in pro-inflammatory AA with a concomitant decrease in anti-inflammatory DHA.
Findings demonstrate relative deficiencies in HbSS of the anti-inflammatory precursor fatty acids DHA and EPA, which correlates positively with hs-CRP.
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Details
- Title
- Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia
- Creators
- B N Yamaja Setty - Thomas Jefferson UniversitySuhita Gayen Betal - Alfred I. duPont Hospital for ChildrenRobin E Miller - Alfred I. duPont Hospital for ChildrenDawn S Brown - Alfred I. duPont Hospital for ChildrenMaureen Meier - St. Christopher's Hospital for ChildrenMichele Cahill - St. Christopher's Hospital for ChildrenNorma B Lerner - St. Christopher's Hospital for ChildrenNataly Apollonsky - St. Christopher's Hospital for ChildrenMarie J Stuart - Alfred I. duPont Hospital for Children
- Publication Details
- Prostaglandins, leukotrienes and essential fatty acids, v 146, pp 11-18
- Publisher
- Elsevier
- Grant note
- BTRP U54HL70585; COBRE P20GM109021 / NHLBI (http://dx.doi.org/10.13039/100000050) National Institutes of Health (http://dx.doi.org/10.13039/100000002)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000472703600002
- Scopus ID
- 2-s2.0-85066270043
- Other Identifier
- 991019167865804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Endocrinology & Metabolism