Journal article
Relationship of plasma cytokines and clinical biomarkers to memory performance in HIV
Journal of neuroimmunology, v 265(01-02), 117
15 Dec 2013
PMID: 24210837
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic systemic immune activation and inflammatory processes have been linked to brain dysfunction in medically stable HIV-infected people. We investigated the association between verbal memory performance and plasma concentrations of 13 cytokines measured using multiplexed bead array immunoassay in 74 HIV-seropositive individuals and 50 HIV-seronegative controls. Memory performance was positively related to levels of IL-8 and IFN-γ, and negatively related to IL-10 and IL-18 and to hepatitis C infection. Memory performance was not significantly related to HIV disease markers. The results indicate the importance of systemic immune and inflammatory markers to neurocognitive function in chronic and stable HIV disease.
•In HIV, memory was significantly related to IL-8, IFN-γ, IL-10, IL-18, and hepatitis C.•Memory performance was not significantly related to HIV disease markers.•Inflammatory markers relate to memory function in chronic and stable HIV disease.
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Details
- Title
- Relationship of plasma cytokines and clinical biomarkers to memory performance in HIV
- Creators
- Stephen Correia - Brown UniversityRonald Cohen - Brown UniversityAssawin Gongvatana - Brown UniversitySkye Ross - Miriam HospitalJames Olchowski - Miriam HospitalKathryn Devlin - Miriam HospitalKaren Tashima - Brown UniversityBradford Navia - Tufts UniversitySuzanne Delamonte - Brown University
- Publication Details
- Journal of neuroimmunology, v 265(01-02), 117
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000329005100014
- Scopus ID
- 2-s2.0-84888366090
- Other Identifier
- 991021463613704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Neurosciences