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Journal article
Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate
Aging (Albany, NY.), v 3(12), pp 1206-1212
26 Dec 2011
PMCID: PMC3273901
PMID: 22201071
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have examined the tolerance of the spindle assembly checkpoint (SAC), as measured by the appearance of tetraploid cells in the presence of a microtubule inhibitor, in a series of primary cell strains derived from species with diverse lifespan and body size. We find that the integrity of the SAC varies among these species. There is a robust correlation between the integrity of the SAC and body size, but poor correlation with longevity and parameters of species development (i.e., time of female fertility, gestation length, and postnatal growth rate). The results suggest that fidelity of the SAC co-evolved more closely with the number of mitoses needed to reach adulthood than with species lifespan.
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Details
- Title
- Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate
- Creators
- Antonello Lorenzini - University of BolognaLauren S. FinkThomas StamatoClaudio TorresChristian Sell
- Publication Details
- Aging (Albany, NY.), v 3(12), pp 1206-1212
- Publisher
- Impact Journals LLC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Neurobiology and Anatomy
- Web of Science ID
- WOS:000299617100012
- Scopus ID
- 2-s2.0-84859485989
- Other Identifier
- 991019168900504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology