Journal article
Relationships Between Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor kappa B Ligand (RANKL), and Growth Hormone (GH) Secretory Status in Short Children
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v 22(12), pp 1105-1112
01 Dec 2009
PMID: 20333869
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
GH deficiency places children at risk for decreased bone density and increased fracture rates. The RANKL/RANK/OPG system plays in important role in linking bone formation to bone resorption. Although OPG is thought to be secreted as a compensatory response to states of low bone density, its concentrations have not been found to differ significantly between GH-deficient, acromegalic, and healthy adults.
Aim: To evaluate the associations between OPG and RANKL serum levels and GH secretory status in children.
Children: 54 short children were recruited.
Methods: Serum OPG and RANKL, IGF-I, IGFBP-3, stimulated GH levels, bone DEXA results, and growth velocity were assessed. Regression modeling was used to evaluate significant predictors of OPG and RANKL levels.
Results: There were no significant differences in OPG and RANKL serum levels or bone DEXA results between GH-deficient and GH-sufficient children. A statistically significant quadratic relationship between OPG and IGFBP-3 concentrations was observed.
Conclusions: IGFBP-3 was found to be the only significant predictor of OPG serum levels, allowing us to speculate that increased OPG levels may represent a compensatory response to the missing anabolic actions of IGF-I and/or GH in children with GH deficiency.
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Details
- Title
- Relationships Between Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor kappa B Ligand (RANKL), and Growth Hormone (GH) Secretory Status in Short Children
- Creators
- Janna Flint - Womens & Childrens Hosp, Lafayette, LA 70508 USAShufang Wu - Drexel Univ, Coll Med, St Christophers Hosp Children, Dept Pediat,Sect Endocrinol & Diabet, Philadelphia, PA 19104 USASusan Shott - Rush Univ, Med Ctr, Dept Internal Med, Biostat Unit, Chicago, IL 60612 USAElizabeth Suarez - Drexel UniversityFrancesco De Luca - Drexel Univ, Coll Med, St Christophers Hosp Children, Dept Pediat,Sect Endocrinol & Diabet, Philadelphia, PA 19104 USA
- Publication Details
- JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v 22(12), pp 1105-1112
- Publisher
- Walter De Gruyter
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; College of Medicine
- Web of Science ID
- WOS:000275091200004
- Scopus ID
- 2-s2.0-77349112695
- Other Identifier
- 991019168484304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Pediatrics