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Relationships Between Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor kappa B Ligand (RANKL), and Growth Hormone (GH) Secretory Status in Short Children
Journal article   Peer reviewed

Relationships Between Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor kappa B Ligand (RANKL), and Growth Hormone (GH) Secretory Status in Short Children

Janna Flint, Shufang Wu, Susan Shott, Elizabeth Suarez and Francesco De Luca
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v 22(12), pp 1105-1112
01 Dec 2009
PMID: 20333869

Abstract

Endocrinology & Metabolism Life Sciences & Biomedicine Pediatrics Science & Technology
GH deficiency places children at risk for decreased bone density and increased fracture rates. The RANKL/RANK/OPG system plays in important role in linking bone formation to bone resorption. Although OPG is thought to be secreted as a compensatory response to states of low bone density, its concentrations have not been found to differ significantly between GH-deficient, acromegalic, and healthy adults. Aim: To evaluate the associations between OPG and RANKL serum levels and GH secretory status in children. Children: 54 short children were recruited. Methods: Serum OPG and RANKL, IGF-I, IGFBP-3, stimulated GH levels, bone DEXA results, and growth velocity were assessed. Regression modeling was used to evaluate significant predictors of OPG and RANKL levels. Results: There were no significant differences in OPG and RANKL serum levels or bone DEXA results between GH-deficient and GH-sufficient children. A statistically significant quadratic relationship between OPG and IGFBP-3 concentrations was observed. Conclusions: IGFBP-3 was found to be the only significant predictor of OPG serum levels, allowing us to speculate that increased OPG levels may represent a compensatory response to the missing anabolic actions of IGF-I and/or GH in children with GH deficiency.

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Collaboration types
Domestic collaboration
Web of Science research areas
Endocrinology & Metabolism
Pediatrics
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