Journal article
Relative telomere length and gene expression of shelterin complex proteins among vinyl chloride monomer-exposed workers in China
Environmental and molecular mutagenesis, v 60(4), pp 361-367
01 May 2019
PMID: 30578676
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vinyl chloride monomer (VCM) is a confirmed carcinogen. The effects of VCM on telomeres and the gene expression of telomere complex proteins, shelterin, have not been well studied but could be of potential relevance to the carcinogenic mechanism of VCM and the health surveillance of VCM-exposed workers. A group of 241 VCM-exposed workers and 101 internal controls from the same plant in Shandong, China were recruited and quantitative polymerase chain reaction was preformed to measure relative telomere length (RTL) and gene expression of shelterin proteins. VCM cumulative exposure dose (CED) was estimated for the exposed workers. The differences in RTL and gene expression between groups were compared by Wald test fitted with robust regression. Shorter RTL was observed in VCM-exposed workers than in the controls (P < 0.001) and was related to CED of VCM. Shortened RTL was also significantly related to increasing age (P = 0.012) and high blood pressure (P = 0.056). Levels of gene expression of shelterin components in exposed workers were all lower than in controls except increased TIN2 expression, and the gene expression differences in TIN2 and POT1 among exposed and control groups were significant (P = 0.014 for TIN2 and P < 0.001 for POT1, respectively). VCM exposure is found associated with altered telomere length and gene expression of shelterin components. This provides new insights into the potential carcinogenic mechanisms of VCM and could be helpful for the health surveillance for VCM-exposed workers. Environ. Mol. Mutagen. 60:361-367, 2019. (c) 2018 Wiley Periodicals, Inc.
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Details
- Title
- Relative telomere length and gene expression of shelterin complex proteins among vinyl chloride monomer-exposed workers in China
- Creators
- Guo-Qiao Zheng - Fudan UniversityGuang-Hui Zhang - Fudan UniversityHan-Tian Wu - Fudan Univ, Sch Publ Hlth, Dept Occupat Hlth & Toxicol, 138 Yixueyuan Rd, Shanghai 200032, Peoples R ChinaYu-Ting Tu - Fudan UniversityWei Tian - Fudan UniversityYan Fang - Fudan UniversityYe Lu - Fudan UniversityShi-Yang Gong - Fudan Univ, Sch Publ Hlth, Dept Occupat Hlth & Toxicol, 138 Yixueyuan Rd, Shanghai 200032, Peoples R ChinaYa-Nan Zhang - Fudan UniversityLi-Bo Yu - Fudan UniversityHong Zhang - Shandong Academy of Medical ScienceHua Shao - Shandong Academy of Medical SciencePaul Brandt-Rauf - Drexel UniversityZhao-Lin Xia - Fudan University
- Publication Details
- Environmental and molecular mutagenesis, v 60(4), pp 361-367
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- 2011CB503800 / 973 program; National Basic Research Program of China NSFC30671740; 81072280 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000462888300005
- Scopus ID
- 2-s2.0-85059966258
- Other Identifier
- 991019167966704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Genetics & Heredity
- Toxicology