Journal article
Release of highly hydrophilic drugs from poly(epsilon-caprolactone) matrices
Journal of applied polymer science, v 107(5), pp 3149-3156
05 Mar 2008
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We examine the release of two highly hydrophilic drugs, nicotine and caffeine, from poly(epsilon-caprolactone) (PCL) matrices. We find that the dominant mechanism for drug release is drug diffusion through the PCL matrices. As a result, the rate of drug release (defined by the amount of drug released per unit time) decreases exponentially with time. Coating the drug-carrying particles with a drug-free PCL layer significantly changes the release profile: instead of exponential decay, the release rate exhibits a peak whose location (time) and magnitude vary with the diffusion coefficient of the drug in the polymer and the thickness of the coating. As a result, coating may be used to control the release rate and obtain a relatively constant rate over a period of time. (c) 2007 Wiley. Periodicals, Inc.
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Details
- Title
- Release of highly hydrophilic drugs from poly(epsilon-caprolactone) matrices
- Creators
- Rachel T. Rosenberg - Drexel UniversitySteven J. Siegel - University of PennsylvaniaNily Dan - Drexel University
- Publication Details
- Journal of applied polymer science, v 107(5), pp 3149-3156
- Publisher
- Wiley
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000252748400048
- Scopus ID
- 2-s2.0-39049157461
- Other Identifier
- 991019312438804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Polymer Science