Journal article
Reliable monitoring of respiratory function with home spirometry in people living with amyotrophic lateral sclerosis
Frontiers in neurology, v 16, 1588992
24 Jun 2025
PMID: 40630909
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction Monitoring respiratory function is essential for assessing the progression of Amyotrophic Lateral Sclerosis (ALS) and planning interventions. Remote pulmonary function testing offers a promising alternative to in-clinic visits by reducing participant burden and enabling more frequent and accessible measurements.Methods To evaluate the feasibility and reliability of home-based spirometry in ALS, we built on the Radcliff Study, a fully remote, longitudinal, exploratory study conducted at home by 67 people with ALS (pALS). After an initial training period, participants managed their coaching autonomously, performing spirometry independently or requesting assistance from trained personnel.Results We demonstrate that combining flexible coaching with a predefined automatic quality control protocol yields consistent and reliable spirometry results for tracking respiratory function over time. This approach reveals that home-measured Slow Vital Capacity (SVC) and Forced Vital Capacity (FVC) evolve similarly and follow a linear trajectory throughout the study period (7.7 +/- 4.0 months), in both slow and fast progressor subpopulations.Discussion The observed linearity in respiratory trajectories supports the potential for early and accurate estimation of progression, reinforcing the feasibility of less frequent monitoring without compromising assessment precision and reducing the burden on both pALS and the healthcare system. Furthermore, our results align with reported in-clinic pulmonary tests, validating remote monitoring as a means to promote more equitable and accessible clinical trial designs.
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Details
- Title
- Reliable monitoring of respiratory function with home spirometry in people living with amyotrophic lateral sclerosis
- Creators
- Julian Peller - EvergreenHealth FoundationMarcos A. Trevisan - EvergreenHealth FoundationGaston Bujia - EvergreenHealth FoundationFelipe Aguirre - EvergreenHealth FoundationDiego E. Shalom - Fundación Ciencias Exactas y NaturalesAlan Taitz - EvergreenHealth FoundationStephanie Henze - EvergreenHealth FoundationSilviya Bastola - EvergreenHealth FoundationJason Osik - Bristol-Myers Squibb (United States)Ryan A. Shewcraft - Bristol-Myers Squibb (United States)Peng Jiang - Bristol-Myers Squibb (United States)Joel Schwartz - Bristol-Myers Squibb (United States)Terry Heiman-Patterson - Temple UniversityMichael E. Sherman - Drexel UniversityMatthew F. Wipperman - Regeneron (United States)Oren Levy - Regeneron (United States)Guofa Shou - Eli Lilly (United States)Karl A. Sillay - EvergreenHealth FoundationLyle W. Ostrow - Temple UniversityErnest Fraenkel - Massachusetts Institute of TechnologyJames D. Berry - Massachusetts General HospitalIndu Navar Bingham - Peter Cohen Foundation DBA EverythingALSEsteban G. Roitberg - National University of General San Martín
- Publication Details
- Frontiers in neurology, v 16, 1588992
- Publisher
- Frontiers Media Sa
- Number of pages
- 9
- Grant note
- EverythingALS and Consortium support with lead funding by Bristol Myers Squibb
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001523910900001
- Scopus ID
- 2-s2.0-105011274623
- Other Identifier
- 991022197419404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences